Evidence map›Paper›PMID 26339365›Full record

SynthesisInternational journal of clinical and experimental pathology2015

Cytologic, clinicopathologic, and molecular features of papillary thyroid carcinoma with prominent hobnail features: 10 case reports and systematic literature review.

Young Sub Lee, Yourha Kim, Sora Jeon, Ja Seong Bae, So Lyung Jung, Chan Kwon Jung

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC
In one paragraph

Synthesis in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Cytologic and Clinicopathologic Features of Papillary Thyroid Carcinoma with Prominent Hobnail Features on FNAC.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Young Sub LeeDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea Seoul, Korea.
Yourha KimDepartment of Biomedicine & Health Science, Graduate School, The Catholic University of Korea Seoul, Korea.
Sora JeonDepartment of Biomedicine & Health Science, Graduate School, The Catholic University of Korea Seoul, Korea.
Ja Seong BaeDepartment of Surgery, College of Medicine, The Catholic University of Korea Seoul, Korea.
So Lyung JungDepartment of Radiology, College of Medicine, The Catholic University of Korea Seoul, Korea.
Chan Kwon JungDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hobnail variant of papillary thyroid carcinoma (PTC) is a rare, aggressive variant in which > 30% of the tumor cells have hobnail features. The clinical behavior and pathologic characteristics of these tumors are still unclear due to the rarity of the entity. The present study aimed to investigate cytologic, clinical, pathological, and molecular features of the hobnail variant from our data and from the literature. We retrospectively retrieved 10 cases of hobnail variant from 2,904 consecutive PTC patients. Cytologic and histopathologic slides from those 10 patients were reviewed. We performed molecular analysis for BRAF, ALK, and TERT promoter mutations on paraffin blocks from surgical specimens, and further analyzed the clinicopathologic characteristics of all case reports published in the literature until now. Cytologically, all tumors were characterized by single cells with eccentric nuclei and tapering cytoplasm (comet-like cells), and syncytial or micropapillary clusters with apically placed nuclei resulting in a hobnail appearance in both conventional smears and liquid-based cytology. The BRAF V600E mutation was found in 8 cases (80%) whereas no cases had ALK fusion or TERT promoter mutations. In the literature review of 55 patients including our cases, most patients presented with advanced stage cancer, and disease-specific survival rates were 83%, 71%, and 54% at 5, 10, and 20 years after the initial surgery, respectively. Characteristic cytologic features can allow a preoperative diagnosis of the hobnail variant of PTC based on cytology specimens. Further studies should be performed to identify the molecular genetics of the variant.

Indexed as

Biomarkers, TumorAdultAgedAged, 80 and overAnaplastic Lymphoma KinaseBiopsyCarcinomaCarcinoma, PapillaryDisease-Free SurvivalDNA Mutational AnalysisFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryMaleMiddle AgedALK protein, humanAnaplastic Lymphoma KinaseBiomarkers, TumorBRAF protein, humanProto-Oncogene Proteins B-rafReceptor Protein-Tyrosine KinasesTelomeraseTERT protein, humanALKBRAFfine needle aspirationhobnail variantTERTThyroid cancer

Identifiers

PMID26339365
PMCPMC4555693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.