SynthesisInternational journal of clinical and experimental pathology2015
Corticosteroid therapy for severe acute pancreatitis: a meta-analysis of randomized, controlled trials.
Synthesis in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- ARDS and corticosteroids: beyond COVID-19.Pneumonia (Nathan Qld.) · 2026Review
- Review
- Acute pancreatitis: Translating early mechanisms to bedside management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Atypical presentation of painless acute pancreatitis: A case report.World journal of clinical cases · 2025Article
- Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomized, placebo controlled clinical trial.Contemporary clinical trials · 2024Article
- Acute pancreatitis: pathogenesis and emerging therapies.Journal of pancreatology · 2024Review
- The causality between use of glucocorticoids and risk of pancreatitis: a Mendelian randomization study.Frontiers in immunology · 2024Article
- Glucocorticoid Treatment in Acute Respiratory Distress Syndrome: An Overview on Mechanistic Insights and Clinical Benefit.International journal of molecular sciences · 2023Review
- A case of hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome with kidney failure and recurrent pancreatitis: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Review
- Glucocorticoids in acute pancreatitis: a propensity score matching analysis.BMC gastroenterology · 2021Article
- Corticosteroid treatment for acute/acute-on-chronic experimental and naturally occurring pancreatitis in several species: a scoping review to inform possible use in dogs.Acta veterinaria Scandinavica · 2021Article
- ACVIM consensus statement on pancreatitis in cats.Journal of veterinary internal medicine · 2021Article
- Undiagnosed sarcoidosis presenting as acute pancreatitis: a rare presentation of a known disease.BMJ case reports · 2021Article
- Medical Management of Chronic Pancreatitis in Children: A Position Paper by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2021Article
- The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis.Frontiers in cell and developmental biology · 2020Review
- Immune thrombocytopenic purpura increased risk of subsequent pancreatitis: A Nationwide population cohort study.Scientific reports · 2019Article
- Pancreatic Involvement in Inflammatory Bowel Disease: A Review.Journal of clinical medicine research · 2018Review
- Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in L-Arginine-Induced Acute Pancreatitis.Digestive diseases and sciences · 2018Article
- Enhancement of ICAM-1 via the JAK2/STAT3 signaling pathway in a rat model of severe acute pancreatitis-associated lung injury.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports about the benefits of corticosteroid therapy in patients with severe acute pancreatitis (SAP) have shown conflicting results. We aimed to explore the effects of corticosteroid therapy in SAP patients on patient outcomes by performing a meta-analysis.
methodsDatabases (Medline, EMBASE, Web of Science, PubMed, Cochrane Library, Chinese Biomedicine Database, and China Academic Journal Full-Text Database) were queried for all relevant, randomized, controlled trials investigating corticosteroid therapy in patients with SAP.
resultsSix randomized, controlled trials including 430 SAP patients were identified. Corticosteroid therapy for SAP was associated with reductions in the length of hospital stay, the need for surgical intervention, and the mortality rate (weighted mean difference [WMD]: -9.47, 95% confidence interval [CI]: -16.91 to -2.04, P = 0.01; odds ratio [OR]: 0.35, 95% CI: 0.18-0.67, P = 0.002; OR: 0.45, 95% CI: 0.22-0.94, P = 0.03). There were no significant differences in the complication rates or Physiology and Chronic Health Evaluation II (APACHE II) scores in patients with or without corticosteroid therapy.
conclusionCorticosteroid therapy may improve outcomes in patients with SAP.
Indexed as
Identifiers
26339332PMC4555660W1670933747What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.