ArticleBiomicrofluidics2015
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.
Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Transdermal needle-free drug delivery approaches and activation mechanism.Materials today. Bio · 2026Review
- Nanofluidic-based electrochemical pump for remotely controlled, on-demand drug delivery.Lab on a chip · 2026Article
- Acoustic Bubble and Magnetic Actuation-Based Microrobot for Enhanced Multiphase Drug Delivery Efficiency.Micromachines · 2023Article
- Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology.Nature communications · 2022Article
- Thermo-Responsive Hydrogel-Based Soft Valves with Annular Actuation Calibration and Circumferential Gripping.Bioengineering (Basel, Switzerland) · 2021Article
- Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery.Micromachines · 2019Article
- Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications.Scientific reports · 2016Article
- A Magnetoresistive Tactile Sensor for Harsh Environment Applications.Sensors (Basel, Switzerland) · 2016Article
- Preface to Special Topic: Microfluidics in Drug Delivery.Biomicrofluidics · 2015Article
- Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes.Biomicrofluidics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.