ReviewThe Yale journal of biology and medicine2015
Prescription Sedative Misuse and Abuse.
Review in The Yale journal of biology and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Toxicity of benzodiazepines in the treatment of insomnia disorders in older adults: a systematic literature review.Croatian medical journal · 2024Pooled it
- Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder.CNS drugs · 2023Trial
- Protective effect of flumazenil infusion in severe acute benzodiazepine toxicity: a pilot randomized trial.European journal of clinical pharmacology · 2021Trial
- Sedative effects of physcion and its modulatory interaction with diazepam: in vivo and in silico evaluation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Assessment of Knowledge, Attitude and Practice Regarding Self-Medication Among Medical and Pharmacy Students at Damascus University: A Cross-Sectional Study.Drug, healthcare and patient safety · 2026Article
- Antecedent sedative use is independently associated with stroke occurrence among west Africans: Evidence from the SIREN case-control study.eNeurologicalSci · 2025Article
- Self-medication practices and the content of home pharmacies in the households of pharmacy and medical students in Zagreb, Croatia, in 2022 with a reference to the findings from 2001 and 1977.Croatian medical journal · 2025Article
- Decreased anxiety through haptic technology patch usage: A case-control comparison.Journal of family medicine and primary care · 2025Article
- Article
- A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database.Scientific reports · 2025Article
- Patterns of Polydrug Use Classes Among a Subset of Latino Male Seasonal Workers in South Florida: A Latent Class Analysis.Journal of agromedicine · 2024Article
- Prevalence and Treatment of Substance Misuse in Older Adults: Beyond Early Adulthood.Substance abuse and rehabilitation · 2024Review
- Two plants improve stress response of a subterranean herbivore by downregulating amphetamine addiction pathways.Frontiers in veterinary science · 2023Article
- Protocol for a scoping review on misuse of psychoactive medicines and its consequences.BMJ open · 2022Article
- Suicide Attempt and Risk of Substance Use Disorders Among Female Youths.JAMA psychiatry · 2022Article
- Depression and ability to work after vestibular schwannoma surgery: a nationwide registry-based matched cohort study on antidepressants, sedatives, and sick leave.Acta neurochirurgica · 2021Article
- Association between relationship quality and concurrent alcohol use and sedative-tranquilizer misuse in middle and later life.Aging & mental health · 2021Article
- Study on the Sleep-Improvement Effects ofFoods (Basel, Switzerland) · 2021Article
- Can oral formulation increase the risk of lormetazepam abuse?Internal and emergency medicine · 2021Article
- Self-Reported Sedative Drug Use Among Students Attending at University of Gondar, Gondar, Northwest, Ethiopia: A Cross-Sectional Study.Substance abuse and rehabilitation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sedatives are widely prescribed for anxiety or insomnia and include benzodiazepines, selective benzodiazepine receptor subtype agonists (z-drugs), and barbiturates. These sedatives are controlled substances due to their potential for misuse and abuse. Misuse is often self-medication (chemical coping) of psychological symptoms in ways unauthorized by the prescriber, usually as dose escalation leading to requests for early refills. Sedatives are abused for euphoric effects, which may have dangerous consequences. Some sedative overdoses can be treated with flumazenil, a reversal agent, along with supportive care. Sedative withdrawal syndrome is treated by tapering the sedative and may require hospitalization. Long-term treatment of sedative addiction requires counseling, often with the help of an addiction-treatment professional.
Indexed as
Identifiers
26339207PMC4553644W2123139969What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.