ReviewMediators of inflammation2015
The Two-Way Association of Periodontal Infection with Systemic Disorders: An Overview.
Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Periodontal health status in cirrhotic patients: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Association between coffee consumption and periodontal diseases: a systematic review and meta-analysis.BMC oral health · 2022Pooled it
- Risk of incident cardiovascular disease in people with periodontal disease: A systematic review and meta-analysis.Clinical and experimental dental research · 2021Pooled it
- Lifestyle Characteristics and Dietary Habits in Romanian Patients with Periodontitis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The impact of organ transplantation on changes in the oral microbiome, particularly on bacteria causing periodontal inflammation - narrative review.Frontiers in cellular and infection microbiology · 2026Review
- The Association of Periodontal Inflammation and Systemic Health Indicators: A Machine Learning Approach.Journal of clinical periodontology · 2025Article
- Epidemiological trends and incidence prediction of periodontal disease based on the Global Burden of Disease study 2021.Frontiers in dental medicine · 2025Article
- Oral microbiota imbalance: A predisposing factor for Henoch-Schönlein Purpura in children.Heliyon · 2024Article
- Awareness of physicians and dentists in Serbia about the association between periodontitis and systemic diseases: a cross-sectional study.BMC oral health · 2023Article
- Exploring an Association between Body Mass Index and Oral Health-A Scoping Review.Diagnostics (Basel, Switzerland) · 2023Article
- The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions.Life (Basel, Switzerland) · 2023Review
- Body Mass Index as a Proxy Indicator for Poor Oral Hygiene Habits in Adult Diabetic Patients.Zdravstveno varstvo · 2022Article
- Exploring the Mechanisms and Association between Oral Microflora and Systemic Diseases.Diagnostics (Basel, Switzerland) · 2022Review
- Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease-A Suggested Preventive Strategy to Reduce the Public Health Burden.International journal of environmental research and public health · 2022Review
- Association of Alzheimer's disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies.Medicine and pharmacy reports · 2022Review
- The effect of periodontitis on recipient outcomes after kidney transplantation.Kidney research and clinical practice · 2022Article
- Prevalence and Risk Factors for Periodontal Disease Among Women Attending Antenatal Care in Public Hospitals, Southwest Ethiopia, 2022: A Multicenter Cross-Sectional Study.Clinical, cosmetic and investigational dentistry · 2022Article
- Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases.Journal of clinical medicine · 2021Article
- Hypertension and Its Associations with Dental Status: Data from the Dental, Oral, Medical Epidemiological (DOME) Nationwide Records-Based Study.Journal of clinical medicine · 2021Article
- Lifestyle Risk Factors and the Population Attributable Fractions for Overweight and Obesity in Chinese Students of Zhejiang Province.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cavity that harbors diverse bacterial populations could also act as a site of origin for spread of pathogenic microorganisms to different body sites, particularly in immunocompromised hosts, patients, the elderly, or the underprivileged. A number of recent publications have advocated that patients with periodontal diseases are more susceptible to metabolic endotoxemia, inflammation, obesity, type 2 diabetes, and other related systemic complications, concluding that periodontal diseases could be a potential contributing risk factor for a wide array of clinically important systemic diseases. However, despite a significant increase in the prevalence of periodontal infections and systemic diseases in the past few decades, the fundamental biological mechanisms of connection between these ailments are still not fully explicated. Consequently, the mechanisms by which this bidirectional damage occurs are being explored with a concentric vision to develop strategies that could prevent or control the complications of these ailments. This paper attempts to summarize and hypothesize the diverse mechanisms that hint to a certain connection between the two prevalent chronic situations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.