ArticleMediators of inflammation2015
HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study.Journal of advanced periodontology & implant dentistry · 2026Article
- Oral health in professional Slovak soccer players: Assessment of dental risks, subgingival microbiota and genetic influences.PloS one · 2026Article
- Association of HLA-A alleles with periodontitis in people living with HIV: A case control study.Research square · 2025Article
- HLA Polymorphisms Linked to the Severity and Extent of Periodontitis in Patients with Type 1 Diabetes from a Brazilian Mixed Population.International journal of environmental research and public health · 2025Article
- Potential susceptibility genes in patients with stage III and IV periodontitis: A whole-exome sequencing pilot study.Biomolecules & biomedicine · 2024Article
- Haplotype-dependent HLA-DRB1-DQB1 susceptibility to occult HBV infection in Xi'an Han population.Molecular genetics & genomic medicine · 2023Article
- Article
- Association betweenThe Journal of international medical research · 2020Article
- Genetic Association of HLA-A*26, -A*31, and -B*51 with Behcet's Disease in Saudi Patients.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human leukocyte antigens (HLA) have a pivotal role in immune response and may be involved in antigen recognition of periodontal pathogens. However, the associations of HLA with chronic periodontitis (CP) have not been previously studied in the Brazilian population. In an attempt to clarify the issue of genetic predisposition to CP, we examined the distribution of HLA alleles, genotypes, and haplotypes in patients from Southern Brazil. One hundred and eight CP patients and 151 healthy and unrelated controls with age-, gender-, and ethnicity-matched were HLA investigated by polymerase chain reaction with sequence specific oligonucleotides. To exclude smoking as a predisposing factor, statistical analyses were performed in the total sample and in nonsmoking individuals. The significant results showed a positive association of the A∗ 02/HLA-B∗ 40 haplotype with CP (total samples: 4.2% versus 0%, Pc = 0.03; nonsmokers: 4.3% versus 0%, Pc = 0.23) and a lower frequency of HLA-B∗ 15/HLA-DRB1∗ 11 haplotype in CP compared to controls (total samples: 0.0% versus 4.3%, Pc = 0.04; nonsmokers: 0 versus 5.1%, P = 1.0). In conclusion, the HLA-A∗ 02/B∗ 40 haplotype may contribute to the development of CP, while HLA-B∗ 15/DRB1∗ 11 haplotype might indicate resistance to disease among Brazilians.
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