ArticleJournal of virology2015
Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.
Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8European journal of immunology · 2025Article
- Late-life Attenuation of Cytomegalovirus-mediated CD8 T Cell Memory Inflation: Shrinking of the Cytomegalovirus Latency Niche.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Lifelong cytomegalovirus and early-LIFE irradiation synergistically potentiate age-related defects in response to vaccination and infection.Aging cell · 2022Article
- Cellular senescence is a key mediator of lung aging and susceptibility to infection.Frontiers in immunology · 2022Review
- Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward.PLoS pathogens · 2021Review
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).European journal of immunology · 2021Review
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection.Frontiers in immunology · 2021Article
- Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.GeroScience · 2020Review
- Vaccine Vectors Harnessing the Power of Cytomegaloviruses.Vaccines · 2019Review
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).European journal of immunology · 2019Article
- Impact of CMV upon immune aging: facts and fiction.Medical microbiology and immunology · 2019Review
- 'From immunosenescence to immune modulation': a re-appraisal of the role of cytomegalovirus as major regulator of human immune function.Medical microbiology and immunology · 2019Review
- Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?GeroScience · 2019Article
- Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The twilight of immunity: emerging concepts in aging of the immune system.Nature immunology · 2018Review
- CMV immune evasion and manipulation of the immune system with aging.GeroScience · 2017Article
- A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.GeroScience · 2017Review
- Age-related alterations in immune responses to West Nile virus infection.Clinical and experimental immunology · 2017Review
- Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Cell host & microbe · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.