Evidence map›Paper›PMID 26339045›Full record

ArticleJournal of virology2015

Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice.

Goran Gregorovic, Elizabeth A Boulden, Rachel Bosshard, Claudio Elgueta Karstegl, Rebecca Skalsky, Bryan R Cullen, Cornelia Gujer, Patrick Rämer, Christian Münz, Paul J Farrell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Review
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  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
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  14. Review
  15. Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  16. Roles of Non-coding RNAs During Herpesvirus Infection.Current topics in microbiology and immunology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Goran GregorovicSection of Virology, Imperial College, London, United Kingdom.
Elizabeth A BouldenSection of Virology, Imperial College, London, United Kingdom.
Rachel BosshardSection of Virology, Imperial College, London, United Kingdom.
Claudio Elgueta KarsteglSection of Virology, Imperial College, London, United Kingdom.
Rebecca SkalskyDepartment of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina, USA.
Bryan R CullenDepartment of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina, USA.
Cornelia GujerViral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
Patrick RämerViral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
Christian MünzViral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
Paul J FarrellSection of Virology, Imperial College, London, United Kingdom p.farrell@imperial.ac.uk.
Imperial College London · GBUniversity of Zurich · CHDuke Medical Center · USDuke University Hospital · US

Funding

Role and mechanism of action of Gamma herpesvirus microRNAsR01AI067968 · NIAID · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2006 to 2016
$3.6M
NCI NIH HHS T32-CA90111NIAID NIH HHS R01 AI067968NIAID NIH HHS R01-AI067968Worldwide Cancer Research 14-1033
6 · The paper itself

Abstract

Functions of Epstein-Barr virus (EBV)-encoded RNAs (EBERs) were tested in lymphoblastoid cell lines containing EBER mutants of EBV. Binding of EBER1 to ribosomal protein L22 (RPL22) was confirmed. Deletion of EBER1 or EBER2 correlated with increased levels of cytoplasmic EBV LMP2 RNA and with small effects on specific cellular microRNA (miRNA) levels, but protein levels of LMP1 and LMP2A were not affected. Wild-type EBV and EBER deletion EBV had approximately equal abilities to infect immunodeficient mice reconstituted with a human hematopoietic system.

Indexed as

AnimalsCell LineCisplatinHerpesvirus 4, HumanHumansMiceMice, KnockoutMice, SCIDMicroRNAsRibosomal ProteinsRNA-Binding ProteinsRNA, ViralTumor Suppressor Protein p53Viral Matrix ProteinsCisplatinEBV-associated membrane antigen, Epstein-Barr virusEpstein-Barr virus encoded RNA 1Epstein-Barr virus encoded RNA 2MicroRNAsRibosomal ProteinsRNA-Binding ProteinsRNA, ViralRPL22 protein, humanTumor Suppressor Protein p53Viral Matrix Proteins

Identifiers

PMID26339045
PMCPMC4645642
OpenAlexW2343764780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.