ArticleAJNR. American journal of neuroradiology2015
Gray Matter Volume Reduction Is Associated with Cognitive Impairment in Neuromyelitis Optica.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Association of peripapillary retinal nerve fiber layer atrophy with cognitive impairment in patients with neuromyelitis optica spectrum disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Brain tissue integrity in neuromyelitis optica spectrum disorder through T1-w/T2-w ratio, MTR and DTI.Journal of neurology · 2025Article
- Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders.Scientific reports · 2024Article
- Correlation of GABABrain and behavior · 2024Article
- Cognitive function and brain magnetic resonance imaging profiles in neuromyelitis optica spectrum disorder and multiple sclerosis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study).Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Enlarged choroid plexus related to cortical atrophy in multiple sclerosis.European radiology · 2023Article
- Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis.Frontiers in neurology · 2023Article
- Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.NeuroImage. Clinical · 2023Article
- Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder.Scientific reports · 2022Article
- Chronic Cognitive Impairment in AQP4+ NMOSD With Improvement in Cognition on Eculizumab: A Report of Two Cases.Frontiers in neurology · 2022Article
- Altered Microstructure of Cerebral Gray Matter in Neuromyelitis Optica Spectrum Disorder-Optic Neuritis: A DKI Study.Frontiers in neuroscience · 2021Article
- Cognitive impairment in NMOSD-More questions than answers.Brain and behavior · 2020Review
- Cortical Thinning and Ventricle Enlargement in Neuromyelitis Optica Spectrum Disorders.Frontiers in neurology · 2020Article
- Visualizing the Central Nervous System: Imaging Tools for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Frontiers in neurology · 2020Review
- Deep Gray Matter Iron Content in Neuromyelitis Optica and Multiple Sclerosis.BioMed research international · 2020Article
- Transdiagnostic hippocampal damage patterns in neuroimmunological disorders.NeuroImage. Clinical · 2020Article
- Altered neurovascular coupling in neuromyelitis optica.Human brain mapping · 2019Article
- Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeWhether gray matter impairment occurs in neuromyelitis optica is a matter of ongoing debate, and the association of gray matter impairment with cognitive deficits remains largely unknown. The purpose of this study was to investigate gray matter volume reductions and their association with cognitive decline in patients with neuromyelitis optica. MATERIALS AND
methodsThis study included 50 patients with neuromyelitis optica and 50 sex-, age-, handedness-, and education-matched healthy subjects who underwent high-resolution structural MR imaging examinations and a battery of cognitive assessments. Gray matter volume and cognitive differences were compared between the 2 groups. The correlations of the regional gray matter volume with cognitive scores and clinical variables were explored in the patients with neuromyelitis optica.
resultsCompared with healthy controls (635.9 ± 51.18 mL), patients with neuromyelitis optica (602.8 ± 51.03 mL) had a 5.21% decrease in the mean gray matter volume of the whole brain (P < .001). The significant gray matter volume reduction in neuromyelitis optica affected the frontal and temporal cortices and the right thalamus (false discovery rate correction, P < .05). The regional gray matter volumes in the frontal and temporal cortices were negatively correlated with disease severity in patients with neuromyelitis optica (Alphasim correction, P < .05). Patients with neuromyelitis optica had impairments in memory, information processing speed, and verbal fluency (P < .05), which were correlated with gray matter volume reductions in the medial prefrontal cortex and thalamus (Alphasim correction, P < .05).
conclusionsGray matter volume reduction is present in patients with neuromyelitis optica and is associated with cognitive impairment and disease severity in this group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.