Evidence map›Paper›PMID 26338910›Full record

ArticleAJNR. American journal of neuroradiology2015

Parametric Response Mapping of Apparent Diffusion Coefficient as an Imaging Biomarker to Distinguish Pseudoprogression from True Tumor Progression in Peptide-Based Vaccine Therapy for Pediatric Diffuse Intrinsic Pontine Glioma.

R Ceschin, B F Kurland, S R Abberbock, B M Ellingson, H Okada, R I Jakacki, I F Pollack, A Panigrahy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

R CeschinFrom the Departments of Radiology (R.C., A.P.) Biomedical Informatics (R.C., A.P.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Departments of Radiology (R.C., A.P.).
B F KurlandChildren's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.) Department of Biostatistics, Graduate School of Public Health (B.F.K.), University of Pittsburgh, Pittsburgh, Pennsylvania.
S R AbberbockChildren's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.).
B M EllingsonDepartment of Radiological Sciences (B.M.E.), University of California, Los Angeles, Los Angeles, California.
H OkadaSurgery (H.O.) Neurosurgery (H.O., I.F.P.) Immunology (H.O.) Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.).
R I JakackiPediatrics (R.I.J.) Pediatrics (R.I.J.) Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.).
I F PollackNeurosurgery (H.O., I.F.P.) Neurosurgery (I.F.P.) Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.).
A PanigrahyFrom the Departments of Radiology (R.C., A.P.) Biomedical Informatics (R.C., A.P.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Departments of Radiology (R.C., A.P.) Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute (B.F.K., S.R.A., H.O., R.I.J., I.F.P., A.P.) panigrahya@upmc.edu.
Children's Hospital of Pittsburgh · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SKUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
Vector delivery to modify the brain tumor and its microenvironmentP01NS040923 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLORIOSO, JOSEPH C · 2002 to 2012
$12.7M
Peptide-Based Vaccine Therapy for Childhood Malignant GliomasR21CA149872 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OKADA, HIDEHO, POLLACK, IAN F. · 2010 to 2011
$619k
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NCI NIH HHS P30 CA047904NCI NIH HHS P30CA47904NCI NIH HHS R21 CA149872NCI NIH HHS R21CA149872NCRR NIH HHS UL1 RR024153NINDS NIH HHS P01 NS040923NINDS NIH HHS P01NS40923NLM NIH HHS 5T15LM007059-27NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

background and purposeImmune response to cancer therapy may result in pseudoprogression, which can only be identified retrospectively and may disrupt an effective therapy. This study assesses whether serial parametric response mapping (a voxel-by-voxel method of image analysis also known as functional diffusion mapping) analysis of ADC measurements following peptide-based vaccination may help prospectively distinguish progression from pseudoprogression in pediatric patients with diffuse intrinsic pontine gliomas. MATERIALS AND

methodsFrom 2009 to 2012, 21 children, 4-18 years of age, with diffuse intrinsic pontine gliomas were enrolled in a serial peptide-based vaccination protocol following radiation therapy. DWI was acquired before immunotherapy and at 6-week intervals during vaccine treatment. Pseudoprogression was identified retrospectively on the basis of clinical and radiographic findings, excluding DWI. Parametric response mapping was used to analyze 96 scans, comparing ADC measures at multiple time points (from the first vaccine to up to 12 weeks after the vaccine was halted) with prevaccine baseline values. Log-transformed fractional increased ADC, fractional decreased ADC, and parametric response mapping ratio (fractional increased ADC/fractional decreased ADC) were compared between patients with and without pseudoprogression, by using generalized estimating equations with inverse weighting by cluster size.

resultsMedian survival was 13.1 months from diagnosis (range, 6.4-24.9 months). Four of 21 children (19%) were assessed as experiencing pseudoprogression. Patients with pseudoprogression had higher fitted average log-transformed parametric response mapping ratios (P = .01) and fractional decreased ADCs (P = .0004), compared with patients without pseudoprogression.

conclusionsSerial parametric response mapping of ADC, performed at multiple time points of therapy, may distinguish pseudoprogression from true progression in patients with diffuse intrinsic pontine gliomas treated with peptide-based vaccination.

Indexed as

AdolescentBrain Stem NeoplasmsCancer VaccinesChildChild, PreschoolDiffusion Magnetic Resonance ImagingDisease ProgressionFemaleGliomaHumansImage Interpretation, Computer-AssistedImmunizationMaleRetrospective StudiesCancer Vaccines

Identifiers

PMID26338910
PMCPMC4644687
OpenAlexW2181052326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.