ArticleEuropean journal of medical research2015
A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h.
Article in European journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- Extraterrestrial regolith is hemostatic and potentially suitable for hemorrhage control in space.Research and practice in thrombosis and haemostasis · 2026Article
- Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.Cells · 2024Article
- A dumbbell rescue stent graft facilitates clamp-free repair of aortic injury in a porcine model.JVS-vascular science · 2023Article
- Club cell protein (CC)16 as potential lung injury marker in a porcine 72 h polytrauma model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Blast polytrauma with hemodynamic shock, hypothermia, hypoventilation and systemic inflammatory response: description of a new porcine model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs.PloS one · 2022Article
- Complement Activation and Organ Damage After Trauma-Differential Immune Response Based on Surgical Treatment Strategy.Frontiers in immunology · 2020Article
- A Simple Cardiovascular Model for the Study of Hemorrhagic Shock.Computational and mathematical methods in medicine · 2020Article
- Nerve grafting for peripheral nerve injuries with extended defect sizes.Wiener medizinische Wochenschrift (1946) · 2019Review
- New hemostatic device for grade IV-V liver injury in porcine model: a proof of concept.World journal of emergency surgery : WJES · 2019Article
- Trauma Severity and Its Impact on Local Inflammation in Extremity Injury-Insights From a Combined Trauma Model in Pigs.Frontiers in immunology · 2019Article
- Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism.Frontiers in immunology · 2019Article
- Cardiac Depression in Pigs after Multiple Trauma - Characterization of Posttraumatic Structural and Functional Alterations.Scientific reports · 2017Article
- Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma.Scientific reports · 2016Article
- Long-Term Effects of Induced Hypothermia on Local and Systemic Inflammation - Results from a Porcine Long-Term Trauma Model.PloS one · 2016Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy.
methodsA standardized polytrauma including lung contusion, liver laceration and lower leg fracture was applied in 25 pigs. They underwent controlled haemorrhage either with a blood volume loss of 45 % and a median arterial pressure (MAP) <30 mmHg/90 min (group L, n = 15) or a 50 % blood loss of and an MAP <25 mmHg/120 min (group H, n = 10). Five non-traumatized pigs served as a control (group C). Subsequently, intensive care treatment was given for an observational period of 48 h.
resultsBoth trauma groups showed signs of shock and organ injury (heart rate, MAP and lactate). The frequency of cardiopulmonary resuscitation (CPR) and lung injury was directly related to the severity of the haemorrhagic shock (CPR-group L: 4 of 15 pigs, group H: 4 of 10 pigs; Respiratory failure-group L: 3 of 13, group H: 3 of 9. There was no difference in mortality between trauma groups.
conclusionThe present data suggest that our model reflects the mortality and organ failure of polytrauma in humans during shock and the intensive care period. This suggests that the experimental protocol could be useful for the assessment of therapeutic approaches during the post-traumatic period.
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