ArticleJournal of neurology2015
Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia.
Article in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The imaging signature of C9orf72 hexanucleotide repeat expansions: implications for clinical trials and therapy development.Brain imaging and behavior · 2021Pooled it
- Changes in body composition in genetic C9orf72 carriers: The role of the hypothalamus and thalamus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Prenatal maternal stress is associated with alterations in the structural integrity of the hypothalamic-pituitary-gonadal axis 20 years later: Project Ice Storm.Human reproduction (Oxford, England) · 2026Article
- Genetic pathways linking oxytocin-vasotocin hypothalamic subunit architecture with psychiatric and metabolic traits.Molecular psychiatry · 2026Article
- Article
- Multimodal MRI reveals hypothalamic structural-functional alterations associated with bone mineral density loss in postmenopausal women.Brain imaging and behavior · 2026Article
- Hypothalamic subunit atrophy and glymphatic dysfunction in idiopathic hypogonadotropic hypogonadism: associations with cognitive impairment.BMC medical imaging · 2025Article
- Characteristic volume, texture, and functional connectivity alterations in hypothalamic subunits of adult primary hypothyroidism: a multiparametric MRI analysis.Journal of endocrinological investigation · 2025Article
- Nocturnal sleep dynamics alterations in the early stages of behavioral variant frontotemporal dementia.Sleep · 2025Article
- Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studies.EBioMedicine · 2025Article
- Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia.Neurology · 2024Observational
- High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models.Scientific data · 2024Article
- Hypoperfusion of hypothalamic subunits in medication-overuse headache using a 3D PCASL MRI.Scientific reports · 2024Article
- Association Between Hypothalamic Volume and Metabolism, Cognition, and Behavior in Patients With Amyotrophic Lateral Sclerosis.Neurology · 2024Article
- Volume loss in the left anterior-superior subunit of the hypothalamus in amyotrophic lateral sclerosis.CNS neuroscience & therapeutics · 2024Article
- Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity.Endocrine reviews · 2024Review
- Hypothalamic Subunit Volumes in Schizophrenia and Bipolar Spectrum Disorders.Schizophrenia bulletin · 2024Article
- The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders.Nature human behaviour · 2024Article
- Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans.Nature communications · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17% lower hypothalamic volume compared with controls (p < 0.001): mean 783 (standard deviation 113) versus 944 (73) mm(3) (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.
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