ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Factors Associated With Complications of Clostridium difficile Infection in a Multicenter Prospective Cohort.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection.PloS one · 2019Pooled it
- Effect of the ribotype 027 strain on Clostridioides difficile infection outcomes and recurrence in the Veterans Affairs healthcare system: a propensity scores matching study.BMC infectious diseases · 2026Article
- Review
- Epidemiology ofAntibiotics (Basel, Switzerland) · 2026Article
- Healthcare-AssociatedMicroorganisms · 2025Article
- Patient-reported benefits of colonoscopicallyadministered microbiota restoration therapy: a qualitative study of adult patients with recurrentTherapeutic advances in gastroenterology · 2025Article
- Review
- The Strain and the Clinical Outcome ofOpen forum infectious diseases · 2024Article
- A new score to predict Clostridioides difficile infection in medical patients: a sub-analysis of the FADOI-PRACTICE study.Internal and emergency medicine · 2023Article
- COVID-19 andInfectious disease reports · 2023Article
- Risk Factors of SevereFrontiers in microbiology · 2022Article
- Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.Gut pathogens · 2021Article
- Clostridioides difficile Whole-genome Sequencing Differentiates Relapse With the Same Strain From Reinfection With a New Strain.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Clostridioides difficile infection in a long-term convalescence hospital: A real tale of pitfalls and outdated therapy.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Article
- Higher genome variability within metabolism genes associates with recurrent Clostridium difficile infection.BMC microbiology · 2021Article
- Defining the black box: a narrative review of factors associated with adverse outcomes from severeTherapeutic advances in gastroenterology · 2021Review
- Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore.Scientific reports · 2019Article
- To Lump or To Split: Does Strain Lineage for Clostridioides difficile Matter?Journal of clinical microbiology · 2019Article
- Multilocus Variable-Number Tandem-Repeat Analysis of Clostridioides difficile Clusters in Ribotype 027 Isolates and Lack of Association with Clinical Outcomes.Journal of clinical microbiology · 2019Article
- Colon Surgery Risk With Corticosteroids Versus Immunomodulators or Biologics in Inflammatory Bowel Disease Patients With Clostridium difficile Infection.Inflammatory bowel diseases · 2019Article
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13 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundClostridium difficile infection (CDI) is the most common cause of nosocomial infectious diarrhea and may result in severe complications including death. We conducted a prospective study to identify risk factors for complications of CDI (cCDI).
methodsAdult inpatients with confirmed CDI in 10 Canadian hospitals were enrolled and followed for 90 days. Potential risk factors were measured within 24 hours of diagnosis. Isolates were typed by polymerase chain reaction ribotyping. cCDI was defined as 1 or more of the following: colonic perforation, toxic megacolon, colectomy, admission to an intensive care unit for cCDI, or if CDI contributed to death within 30 days of enrollment. Risk factors for cCDI were investigated by logistic regression.
resultsA total of 1380 patients were enrolled. cCDI was observed in 8% of patients. The ribotype was identified in 922 patients, of whom 52% were infected with R027. Age ≥ 80 years, heart rate >90/minute, respiratory rate >20/minute, white cell count <4 × 10(9)/L or ≥ 20 × 10(9)/L, albumin <25 g/L, blood urea nitrogen >7 mmol/L, and C-reactive protein ≥ 150 mg/L were independently associated with cCDI. A higher frequency of cCDI was observed among R027-infected patients (10.9% vs 7.2%), but the association was not significant in adjusted analysis.
conclusionsCDI complications were associated with older age, abnormal blood tests, and abnormal vital signs. These factors, which are readily available to clinicians at the time of diagnosis, could be used for outcome prediction and risk stratification to select patients who may need closer monitoring or more aggressive therapy.
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