ArticleVeterinary research2015
Bagaza virus is pathogenic and transmitted by direct contact in experimentally infected partridges, but is not infectious in house sparrows and adult mice.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Zoonotic Orthoflaviviruses Related to Birds: A Literature Review.Microorganisms · 2025Review
- Exposure to West Nile Virus in Wild Lagomorphs in Spanish Mediterranean Ecosystems.Zoonoses and public health · 2025Article
- Detection of Bagaza Virus in Europe: A Scoping Review.Veterinary sciences · 2025Review
- Emergence of Two Different Genotypes of Bagaza Virus (BAGV) Affecting Red-Legged Partridges in Spain, in 2019 and 2021.Pathogens (Basel, Switzerland) · 2024Article
- Mice as an Animal Model for Japanese Encephalitis Virus Research: Mouse Susceptibility, Infection Route, and Viral Pathogenesis.Pathogens (Basel, Switzerland) · 2023Review
- Genome Characterization and Spaciotemporal Dispersal Analysis of Bagaza Virus Detected in Portugal, 2021.Pathogens (Basel, Switzerland) · 2023Article
- Bagaza virus and Plasmodium spp. coinfection in red-legged partridges (Alectoris rufa), in Southern Spain 2019.Transboundary and emerging diseases · 2022Article
- Phylogenetic Characterisation of the Full Genome of a Bagaza Virus Isolate from Bird Fatalities in South Africa.Viruses · 2022Article
- Bagaza Virus in Wild Birds, Portugal, 2021.Emerging infectious diseases · 2022Article
- Simultaneous circulation of two West Nile virus lineage 2 clades and Bagaza virus in the Zambezi region, Namibia.PLoS neglected tropical diseases · 2021Article
- Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis.Journal of virology · 2020Review
- Experimental Usutu Virus Infection in Domestic CanariesViruses · 2020Article
- Article
- The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses.Frontiers in microbiology · 2019Article
- Targeting of the Nasal Mucosa by Japanese Encephalitis Virus for Non-Vector-Borne Transmission.Journal of virology · 2018Article
- A Single Mutation at Position 156 in the Envelope Protein of Tembusu Virus Is Responsible for Virus Tissue Tropism and Transmissibility in Ducks.Journal of virology · 2018Article
- Experimental infection of grey partridges with Bagaza virus: pathogenicity evaluation and potential role as a competent host.Veterinary research · 2018Article
- Breeding consequences of flavivirus infection in the collared flycatcher.BMC evolutionary biology · 2018Article
- Complete genome sequence of T'Ho virus, a novel putative flavivirus from the Yucatan Peninsula of Mexico.Virology journal · 2017Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bagaza virus (BAGV) is a mosquito-borne flavivirus belonging to the Ntaya serocomplex. In 2010, a disease outbreak was reported in Cádiz (Southern Spain) affecting game birds (red-legged partridges and common pheasants). In this work, red-legged partridges were inoculated experimentally with infectious BAGV isolated from this outbreak in order to make a complete clinical and analytical assessment of the disease caused by the pathogen in this species. Viral load (by real-time RT-PCR) in blood, oral and cloacal swabs, and feathers, and neutralizing antibody titres (by VNT) were measured. In order to determine direct contact transmission, non-inoculated partridges were caged together with the inoculated ones. To assess infectiousness in other species, house sparrows and mice were also inoculated with the virus. All the inoculated partridges were clinically affected, and 30% of them died. All the infected individuals lost weight, with larger losses being recorded in females. Conversely, no mortality or disease symptoms were observed in the sparrows or mice. Remarkably, all the contact partridges acquired the infection by direct (non-vectored) transmission. This study confirms that the red-legged partridge is a susceptible host for BAGV infection, and that this pathogen is transmitted by direct contact. Long-lasting viral loads detected in calami of immature feathers demonstrate that feather sampling could be a useful strategy in active surveillance programs for early detection of BAGV.
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