ArticleThe Journal of biological chemistry2015
Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.PloS one · 2021Trial
- The Sphingolipid Balance and Endothelial Dysfunction in Lysosomal Storage Diseases: Shared Mechanisms in Gaucher, Niemann-Pick and Fabry Disease.International journal of molecular sciences · 2026Review
- The effects of circulating proteins and metabolites on diabetic foot ulcer: A Mendelian randomization study and mediation analysis.Medicine · 2026Article
- The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.International journal of molecular sciences · 2024Review
- PRC2-dependent regulation of ganglioside expression during dedifferentiation contributes to the proliferation and migration of vascular smooth muscle cells.Frontiers in cell and developmental biology · 2022Article
- GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.International journal of molecular sciences · 2021Article
- Cell Surface and Functional Features of Cortical Bone Stem Cells.International journal of molecular sciences · 2021Article
- Transcriptome of CD8Cancer immunology, immunotherapy : CII · 2021Article
- DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases.Journal of radiation research · 2021Review
- Glycosphingolipids.Advances in experimental medicine and biology · 2021Article
- Article
- Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.Cell communication and signaling : CCS · 2020Article
- Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage.Scientific reports · 2019Article
- Vascular Diseases and Gangliosides.International journal of molecular sciences · 2019Review
- Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor.Cancer science · 2019Article
- Gangliosides Contribute to Vascular Insulin Resistance.International journal of molecular sciences · 2019Review
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- Article
- DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
- Sialylation regulates myofibroblast differentiation of human skin fibroblasts.Stem cell research & therapy · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular endothelial cells (ECs) play central roles in physiologically important functions of blood vessels and contribute to the maintenance of vascular integrity. Therefore, it is considered that the impairment of EC functions leads to the development of vascular diseases. However, the molecular mechanisms of the EC dysfunctions that accompany senescence and aging have not yet been clarified. The carbohydrate antigens carried by glycoconjugates (e.g. glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. In this study, we have investigated the abundance and functional roles of glycosphingolipids in human ECs during senescence and aging. Among glycosphingolipids, ganglioside GM1 was highly expressed in abundance on the surface of replicatively and prematurely senescent ECs and also of ECs derived from an elderly subject. Insulin signaling, which regulates important functions of ECs, is impaired in senescent and aged ECs. Actually, by down-regulating GM1 on senescent ECs and overloading exogenous GM1 onto non-senescent ECs, we showed that an increased abundance of GM1 functionally contributes to the impairment of insulin signaling in ECs. Taken together, these findings provide the first evidence that GM1 increases in abundance on the cell surface of ECs under the conditions of cellular senescence and aging and causes insulin resistance in ECs. GM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.