ArticleBMC genomics2015
Lasting effects of early exposure to temperature on the gonadal transcriptome at the time of sex differentiation in the European sea bass, a fish with mixed genetic and environmental sex determination.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 93 citations in OpenAlex.
- Ultrasonography as a non-invasive technique to assess the effects of diet on the ovaries of female European seabass (Dicentrarchus labrax).Journal of fish biology · 2026Article
- BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells.Environmental epigenetics · 2026Article
- An integrated roadmap of European sea bass (Frontiers in cell and developmental biology · 2026Article
- Multigenerational temperature effects on paternal epigenetic inheritance in European sea bass.Epigenetics & chromatin · 2025Article
- Identification of sex-biased MiRNA markers informative of heat-past events.BMC genomics · 2025Article
- Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia.PLoS genetics · 2025Article
- Effect of high temperatures on sex ratio and differential expression analysis (RNA-seq) of sex-determining genes inEnvironmental epigenetics · 2023Article
- Improved biomarker discovery through a plot twist in transcriptomic data analysis.BMC biology · 2022Article
- Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation.BMC genomic data · 2022Article
- Gonadal bacterial community composition is associated with sex-specific differences in swamp eelsFrontiers in immunology · 2022Article
- Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Transcriptomic Analysis of Gonads from the Low-Temperature-Induced Masculinization ofAnimals : an open access journal from MDPI · 2021Article
- Epigenetic mechanisms in sex determination and in the evolutionary transitions between sexual systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination.PLoS genetics · 2021Article
- Activation of stress response axis as a key process in environment-induced sex plasticity in fish.Cellular and molecular life sciences : CMLS · 2020Review
- Early response to heat stress in Chinese tongue sole (Cynoglossus semilaevis): performance of different sexes, candidate genes and networks.BMC genomics · 2020Article
- Transcriptome Profiling and Analysis of Genes Associated with High Temperature-Induced Masculinization in Sex-Undifferentiated Nile Tilapia Gonad.Marine biotechnology (New York, N.Y.) · 2020Article
- Article
- Heat stress-induced alterations in the expression of genes associated with gonadal integrity of the teleost Puntius sophore.Fish physiology and biochemistry · 2019Article
- Characterization of the European Sea Bass (Dicentrarchus labrax) Gonadal Transcriptome During Sexual Development.Marine biotechnology (New York, N.Y.) · 2019Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex in fish is plastic and in several species can be influenced by environmental factors. In sensitive species, elevated temperatures have a masculinizing effect. Previous studies on the effects of temperature on gene expression have been restricted to a few cognate genes, mostly related to testis or ovarian development, and analyzed in gonads once they had completed the process of sex differentiation. However, studies on the effect of temperature at the whole gonadal transcriptomic level are scarce in fish and, in addition, temperature effects at the time of sex differentiation at the transcriptomic level are also unknown. Here, we used the European sea bass, a gonochoristic teleost with a polygenic sex determination system influenced by temperature, and exposed larvae to elevated temperature during the period of early gonad formation. Transcriptomic analysis of the gonads was carried out about three months after the end of temperature exposure, shortly after the beginning of the process of sex differentiation.
resultsElevated temperature doubled the number of males with respect to untreated controls. Transcriptomic analysis of early differentiating female gonads showed how heat caused: 1) an up-regulation of genes related to cholesterol transport (star), the stress response (nr3c1) and testis differentiation (amh, dmrt, etc.), 2) a decrease in the expression of genes related to ovarian differentiation such as cyp19a1a, and 3) an increase in the expression of several genes related to epigenetic regulatory mechanisms (hdac11, dicer1, ehmt2, jarid2a, pcgf2, suz12, mettl22).
conclusionsTaken together, the results of this study contribute to the understanding of how the early environment sets permanent changes that result in long-lasting consequences, in this case in the sexual phenotype. Results also show the usefulness of comparing the effects of heat on the behavior of cognate genes related to sex differentiation as well as that of genes involved in establishing and maintaining cell identity through epigenetic mechanisms.
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