ArticleScientific reports2015
Whole-genome Sequencing for Tracing the Transmission Link between Two ARD Outbreaks Caused by a Novel HAdV Serotype 7 Variant, China.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- First detection of human adenovirus type 7 deletion mutant associated with an outbreak of acute respiratory infection.Virology journal · 2026Article
- The changed endemic pattern of human adenovirus from species C to B among children in 2022-2024 in Shenzhen, China.Scientific reports · 2026Article
- Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China.Virology journal · 2024Article
- Current status of human adenovirus infection in China.World journal of pediatrics : WJP · 2022Review
- Molecular investigation of a RSV outbreak in a geriatric hospital.BMC geriatrics · 2021Article
- Pneumonia Patients Caused by Co-infection With SARS-CoV-2 and Human Adenovirus in China.Frontiers in medicine · 2021Article
- Review
- Article
- Using hospital administrative data to infer patient-patient contact via the consistent co-presence algorithm.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2019Article
- Detailed Evaluation of Data Analysis Tools for Subtyping of Bacterial Isolates Based on Whole Genome Sequencing:Frontiers in microbiology · 2019Article
- A triplex quantitative real-time PCR assay for differential detection of human adenovirus serotypes 2, 3 and 7.Virology journal · 2018Article
- Circulation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai.Scientific reports · 2017Article
- Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections.Journal of clinical microbiology · 2017Article
- Surveillance for respiratory infectious diseases caused by 6 common viruses in a recruit training site in the Northern region of China.Military Medical Research · 2017Article
- An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015.PloS one · 2017Article
- Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate.Scientific reports · 2016Article
- Epidemiology and transmission characteristics of human adenovirus type 7 caused acute respiratory disease outbreak in military trainees in East China.American journal of translational research · 2016Article
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25 authors.
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Abstract
From December 2012 to February 2013, two outbreaks of acute respiratory disease caused by HAdV-7 were reported in China. We investigated possible transmission links between these two seemingly unrelated outbreaks by integration of epidemiological and whole-genome sequencing (WGS) data. WGS analyses showed that the HAdV-7 isolates from the two outbreaks were genetically indistinguishable; however, a 12 bp deletion in the virus-associated RNA gene distinguished the outbreak isolates from other HAdV-7 isolates. Outbreak HAdV-7 isolates demonstrated increased viral replication compared to non-outbreak associated HAdV-7 isolate. Epidemiological data supported that the first outbreak was caused by introduction of the novel HAdV-7 virus by an infected recruit upon arrival at the training base. Nosocomial transmission by close contacts was the most likely source leading to onset of the second HAdV-7 outbreak, establishing the apparent transmission link between the outbreaks. Our findings imply that in-hospital contact investigations should be encouraged to reduce or interrupt further spread of infectious agents when treating outbreak cases, and WGS can provide useful information guiding infection-control interventions.
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