Evidence map›Paper›PMID 26338666›Full record

ArticleJournal of community genetics2016

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors.

Muni Rubens, Venkataraghavan Ramamoorthy, Jennifer Attonito, Anshul Saxena, Sandeep Appunni, Nancy Shehadeh, Jessy G Dévieux

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Personality as an intermediate phenotype for genetic dissection of alcohol use disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muni RubensRobert Stempel College of Public Health and Social Work, Department of Health Promotion & Disease Prevention, Florida International University, 11200 SW 8th Street, AHC V #405, Miami, FL, 33199, USA. mrube001@fiu.edu.
Venkataraghavan RamamoorthyRobert Stempel College of Public Health and Social Work, Department of Health Promotion & Disease Prevention, Florida International University, 11200 SW 8th Street, AHC V #405, Miami, FL, 33199, USA.
Jennifer AttonitoRobert Stempel College of Public Health and Social Work, Department of Health Promotion & Disease Prevention, Florida International University, 11200 SW 8th Street, AHC V #405, Miami, FL, 33199, USA.
Anshul SaxenaRobert Stempel College of Public Health and Social Work, Department of Health Promotion & Disease Prevention, Florida International University, 11200 SW 8th Street, AHC V #405, Miami, FL, 33199, USA.
Sandeep AppunniDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Nancy ShehadehFlorida Atlantic University, Boca Raton, FL, USA.
Jessy G DévieuxRobert Stempel College of Public Health and Social Work, Department of Health Promotion & Disease Prevention, Florida International University, 11200 SW 8th Street, AHC V #405, Miami, FL, 33199, USA.

Funding

Intervening with HIV+ Alcohol Abusers: Influence of Neuro-Behavioral FactorsR01AA017405 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI DEVIEUX, JESSY G. · 2007 to 2011
$3.6M
NIAAA NIH HHS R01 AA017405
6 · The paper itself

Abstract

Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.

Indexed as

5-HTTLPR polymorphismAlcohol cessation programsAlcohol use problemsRisky sexual behaviorsSTI/HIV prevention programs

Identifiers

PMID26338666
PMCPMC4715809

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.