ArticleScientific reports2015
Molecular Evolution of the Capsid Gene in Norovirus Genogroup I.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The emergence and evolutionary advantage of the novel epidemic norovirus GII.17 lineage.Archives of virology · 2026Article
- Superior RdRp Function Drives the Dominance of Prevalent GI.3 Norovirus Lineages.Microorganisms · 2025Article
- Predicting Dominant Genotypes in Norovirus Seasons in Japan.Life (Basel, Switzerland) · 2023Article
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- Illuminating Human Norovirus: A Perspective on Disinfection of Water and Surfaces Using UVC, Norovirus Model Organisms, and Radiation Safety Considerations.Pathogens (Basel, Switzerland) · 2022Article
- Molecular Evolution of Classic Human Astrovirus, as Revealed by the Analysis of the Capsid Protein Gene.Viruses · 2019Article
- Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012-2018.Gut pathogens · 2019Article
- Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II.Frontiers in microbiology · 2018Article
- Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity.PLoS pathogens · 2017Article
- Molecular Evolution of theFrontiers in microbiology · 2017Article
- Molecular Evolution of the RNA-Dependent RNA Polymerase and Capsid Genes of Human Norovirus Genotype GII.2 in Japan during 2004-2015.Frontiers in microbiology · 2017Article
- Molecular evolution of the capsid gene in human norovirus genogroup II.Scientific reports · 2016Article
- Human norovirus transmission and evolution in a changing world.Nature reviews. Microbiology · 2016Review
- Human norovirus hyper-mutation revealed by ultra-deep sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1-9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also performed selective pressure analysis and B-cell linear epitope prediction in the deduced NoV GI capsid protein. Furthermore, we analysed the effective population size of the virus using Bayesian skyline plot (BSP) analysis. A phylogenetic tree by MCMC showed that NoV GI diverged from the common ancestor of NoV GII, GIII, and GIV approximately 2,800 years ago with rapid evolution (about 10(-3) substitutions/site/year). Some positive selection sites and over 400 negative selection sites were estimated in the deduced capsid protein. Many epitopes were estimated in the deduced virus capsid proteins. An epitope of GI.1 may be associated with histo-blood group antigen binding sites (Ser377, Pro378, and Ser380). Moreover, BSP suggested that the adaptation of NoV GI strains to humans was affected by natural selection. The results suggested that NoV GI strains evolved rapidly and date back to many years ago. Additionally, the virus may have undergone locally affected natural selection in the host resulting in its adaptation to humans.
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