ArticleLab on a chip2015
A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- An Acoustofluidic Device for Sample Preparation and Detection of Small Extracellular Vesicles.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- [High stability enhanced ultrasonic microfluidic structure with flexible tip coupled bubbles].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Microfluidic Continuous Flow DNA Fragmentation based on a Vibrating Sharp-tip.Microfluidics and nanofluidics · 2022Article
- A Concentration Gradients Tunable Generator with Adjustable Position of the Acoustically Oscillating Bubbles.Micromachines · 2020Article
- A Review of Passive Micromixers with a Comparative Analysis.Micromachines · 2020Review
- An acoustofluidic device for efficient mixing over a wide range of flow rates.Lab on a chip · 2020Article
- 3D Printed Multiplexed Competitive Migration Assays with Spatially Programmable Release Sources.Advanced biosystems · 2020Article
- Cell lysis via acoustically oscillating sharp edges.Lab on a chip · 2019Article
- Mixing Performance of a Cost-effective Split-and-Recombine 3D Micromixer Fabricated by Xurographic Method.Micromachines · 2019Article
- Acoustofluidic Synthesis of Particulate Nanomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- On-chip stool liquefaction via acoustofluidics.Lab on a chip · 2019Article
- Imaging the Dynamic Interaction Between Sprouting Microvessels and the Extracellular Matrix.Frontiers in physiology · 2019Review
- A sharp-edge-based acoustofluidic chemical signal generator.Lab on a chip · 2018Article
- Acoustofluidic devices controlled by cell phones.Lab on a chip · 2018Article
- Biomechanical Characterization at the Cell Scale: Present and Prospects.Frontiers in physiology · 2018Review
- Acoustic streaming: an arbitrary Lagrangian-Eulerian perspective.Journal of fluid mechanics · 2017Article
- Multifunctional single beam acoustic tweezer for non-invasive cell/organism manipulation and tissue imaging.Scientific reports · 2016Article
- Acoustofluidic actuation of in situ fabricated microrotors.Lab on a chip · 2016Article
- Investigation of micromixing by acoustically oscillated sharp-edges.Biomicrofluidics · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The ability to generate stable, spatiotemporally controllable concentration gradients is critical for resolving the dynamics of cellular response to a chemical microenvironment. Here we demonstrate an acoustofluidic gradient generator based on acoustically oscillating sharp-edge structures, which facilitates in a step-wise fashion the rapid mixing of fluids to generate tunable, dynamic chemical gradients. By controlling the driving voltage of a piezoelectric transducer, we demonstrated that the chemical gradient profiles can be conveniently altered (spatially controllable). By adjusting the actuation time of the piezoelectric transducer, moreover, we generated pulsatile chemical gradients (temporally controllable). With these two characteristics combined, we have developed a spatiotemporally controllable gradient generator. The applicability and biocompatibility of our acoustofluidic gradient generator are validated by demonstrating the migration of human dermal microvascular endothelial cells (HMVEC-d) in response to a generated vascular endothelial growth factor (VEGF) gradient, and by preserving the viability of HMVEC-d cells after long-term exposure to an acoustic field. Our device features advantages such as simple fabrication and operation, compact and biocompatible device, and generation of spatiotemporally tunable gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.