ArticleGenes & development2015
Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Roles of Type 10 17β-Hydroxysteroid Dehydrogenase in Health and Disease.Journal of personalized medicine · 2025Review
- Milestones in the development ofJournal of bacteriology · 2025Review
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- Comprehensive Insights into Potential Metabolic Functions of Myxococcota in Activated Sludge Systems.Microbes and environments · 2024Article
- Mitochondrial Quality Control: Its Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).Journal of obesity & metabolic syndrome · 2023Review
- Involvement of Type 10 17β-Hydroxysteroid Dehydrogenase in the Pathogenesis of Infantile Neurodegeneration and Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Allopatric divergence of cooperators confers cheating resistance and limits effects of a defector mutation.BMC ecology and evolution · 2022Article
- 3-Hydroxyacyl-CoA and Alcohol Dehydrogenase Activities of Mitochondrial Type 10 17β-Hydroxysteroid Dehydrogenase in Neurodegeneration Study.Journal of Alzheimer's disease : JAD · 2022Article
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Linking single-cell decisions to collective behaviours in social bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Metabolic Alterations Caused by Defective Cardiolipin Remodeling in Inherited Cardiomyopathies.Life (Basel, Switzerland) · 2020Review
- Data-Driven Models Reveal Mutant Cell Behaviors Important for Myxobacterial Aggregation.mSystems · 2020Article
- Mitochondria as intracellular signaling platforms in health and disease.The Journal of cell biology · 2020Review
- Ultrasensitive Response of Developing Myxococcus xanthus to the Addition of Nutrient Medium Correlates with the Level of MrpC.Journal of bacteriology · 2018Article
- Fatty Acid Oxidation Is Required for Myxococcus xanthus Development.Journal of bacteriology · 2018Article
- Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development.Trends in genetics : TIG · 2017Review
- Role of Cardiolipin in Mitochondrial Signaling Pathways.Frontiers in cell and developmental biology · 2017Review
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins. We show that CsgA and SocA, a protein that can replace CsgA function in vivo, oxidize the 2'-OH glycerol moiety on cardiolipin and phosphatidylglycerol to produce diacylglycerol (DAG), dihydroxyacetone, and orthophosphate. A lipid extract enriched in DAGs from wild-type cells initiates development and lipid body production in a csgA mutant to bypass the mutational block. This novel phospholipase C-like reaction is widespread. SCADs that prevent neurodegenerative disorders, such as Drosophila Sniffer and human HSD10, oxidize cardiolipin with similar kinetic parameters. HSD10 exhibits a strong preference for cardiolipin with oxidized fatty acids. This activity is inhibited in the presence of the amyloid β peptide. Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin. We suggest that HSD10 protects humans from reactive oxygen species by removing damaged cardiolipin before it induces apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.