Evidence map›Paper›PMID 26338062›Full record

ArticleDer Internist2015

[Erythropoiesis: Physiology, pathophysiology, and algorithm for classification of the type of anemia].

J Fandrey, M Hallek

Abstract readEnglish Abstract
PubMed Publisher
In one paragraph

Article in Der Internist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J FandreyInstitut für Physiologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland, joachim.fandrey@uni-due.de.
M Hallek

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythropoiesis is a continuous process that replaces 1% of all erythrocytes per day. To keep the erythrocyte count within stable limits about 3 million cells/s must be renewed. This enormous turnover requires folic acid and vitamin B12 for proper cell differentiation and iron for sufficient haemoglobin synthesis. In particular, iron metabolism underlies a precise regulation which may be disturbed by chronic bleeding, inflammatory disease or impaired dietary intake. If the loss of red blood cells due to physiological aging or bleeding is not balanced by sufficient erythropoiesis in the bone marrow, anaemia will develop. For the classification of various types of anaemia, a well-established algorithm has been proven useful. This algorithm addresses basic questions such as erythrocyte volume, the underlying mechanism, e.g. whether too many cells are destroyed or new cells are not sufficiently generated, and finally aims to define the main causes for the above identified disturbance of erythropoiesis.

Indexed as

AlgorithmsErythrocyte IndicesErythropoiesisAnemiaErythrocytesErythropoietinHumansIronModels, BiologicalErythropoietinIron

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.