ArticleParasitology2016
Pertussis immunity and epidemiology: mode and duration of vaccine-induced immunity.
Article in Parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acellular pertussis vaccines effectiveness over time: A systematic review, meta-analysis and modeling study.PloS one · 2018Pooled it
- Delayed introduction, transmission variation and susceptible dynamics explain spatial asynchrony during Republic of Korea's large pertussis outbreak.Journal of the Royal Society, Interface · 2026Article
- Quantifying the impact of vaccination on pertussis dynamics in Sweden.PLoS computational biology · 2026Article
- A heterogeneous continuous age-structured model of mumps with vaccine.Infectious Disease Modelling · 2025Article
- Laboratory, epidemiological and clinical characteristics of pertussis in children and close contacts: a cross-sectional study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Disentangling the causes of mumps reemergence in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dissecting recurrent waves of pertussis across the boroughs of London.PLoS computational biology · 2022Review
- Sensitivity theorems of a model of multiple imperfect vaccines for COVID-19.Chaos, solitons, and fractals · 2022Article
- Article
- A computational framework for modeling and studying pertussis epidemiology and vaccination.BMC bioinformatics · 2020Article
- Age-structure and transient dynamics in epidemiological systems.Journal of the Royal Society, Interface · 2019Article
- Quantifying the consequences of measles-induced immune modulation for whooping cough epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Commentary: resolving pertussis resurgence and vaccine immunity using mathematical transmission models.Human vaccines & immunotherapeutics · 2019Article
- Assessing systemic and non-systemic transmission risk of tick-borne encephalitis virus in Hungary.PloS one · 2019Article
- A Network-Based Compartmental Model For The Spread Of Whooping Cough In Nebraska.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019Article
- The impact of past vaccination coverage and immunity on pertussis resurgence.Science translational medicine · 2018Article
- Prolonging herd immunity to cholera via vaccination: Accounting for human mobility and waning vaccine effects.PLoS neglected tropical diseases · 2018Article
- Modeling and inference for infectious disease dynamics: a likelihood-based approach.Statistical science : a review journal of the Institute of Mathematical Statistics · 2018Article
- Vaccine impact in homogeneous and age-structured models.Journal of mathematical biology · 2017Article
- Surveillance of Vaccination Coverage among Adult Populations - United States, 2015.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The resurgence of pertussis in some countries that maintain high vaccination coverage has drawn attention to gaps in our understanding of the epidemiological effects of pertussis vaccines. In particular, major questions surround the nature, degree and durability of vaccine protection. To address these questions, we used mechanistic transmission models to examine regional time series incidence data from Italy in the period immediately following the introduction of acellular pertussis (aP) vaccine. Our results concur with recent animal-challenge experiments wherein infections in aP-vaccinated individuals proved as transmissible as those in naive individuals but much less symptomatic. On the other hand, the data provide evidence for vaccine-driven reduction in susceptibility, which we quantify via a synthetic measure of vaccine impact. As to the precise nature of vaccine failure, the data do not allow us to distinguish between leakiness and waning of vaccine immunity, or some combination of these. Across the range of well-supported models, the nature and duration of vaccine protection, the age profile of incidence and the range of projected epidemiological futures differ substantially, underscoring the importance of the remaining unknowns. We identify key data gaps: sources of data that can supply the information needed to eliminate these remaining uncertainties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.