ArticlePharmaceutical research2016
Electrospun Zein/PCL Fibrous Matrices Release Tetracycline in a Controlled Manner, Killing Staphylococcus aureus Both in Biofilms and Ex Vivo on Pig Skin, and are Compatible with Human Skin Cells.
Article in Pharmaceutical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Selective Delivery of Clindamycin Using a Combination of Bacterially Sensitive Microparticle and Separable Effervescent Microarray Patch on Bacteria Causing Diabetic Foot Infection.Pharmaceutical research · 2024Article
- Development ofMolecular pharmaceutics · 2023Article
- An in vitro and ex vivo wound infection model to test topical and systemic treatment with antibiotics.Journal of applied microbiology · 2022Article
- Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(Pharmaceutics · 2022Article
- Bio-Mimicking Acellular Wet Electrospun Scaffolds Promote Accelerated Integration and Re-Epithelialization of Full-Thickness Dermal Wounds.Bioengineering (Basel, Switzerland) · 2022Article
- Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances.Journal of functional biomaterials · 2021Review
- Protein-Based Systems for Topical Antibacterial Therapy.Frontiers in medical technology · 2021Review
- Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges.Pharmaceutics · 2020Review
- Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: A proof of concept study.International journal of pharmaceutics: X · 2020Article
- Evaluation of an Explanted Porcine Skin Model to Investigate Infection with the Dermatophyte Trichophyton rubrum.Mycopathologia · 2020Article
- Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin.Pharmaceutics · 2019Article
- Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release.Pharmaceutics · 2019Review
- Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery.Pharmaceutics · 2018Review
- Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications.Pharmaceutics · 2018Review
- Options and Limitations in Clinical Investigation of Bacterial Biofilms.Clinical microbiology reviews · 2018Review
- Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures.Scientific reports · 2018Article
- Electrospun Zein Fibers Incorporating Poly(glycerol sebacate) for Soft Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the destruction of clinically-relevant bacteria within biofilms via the sustained release of the antibiotic tetracycline from zein-based electrospun polymeric fibrous matrices and to demonstrate the compatibility of such wound dressing matrices with human skin cells.
methodsZein/PCL triple layered fibrous dressings with entrapped tetracycline were electrospun. The successful entrapment of tetracycline in these dressings was validated. The successful release of bioactive tetracycline, the destruction of preformed biofilms, and the viability of fibroblast (FEK4) cells were investigated.
resultsThe sustained release of tetracycline from these matrices led to the efficient destruction of preformed biofilms from Staphylococcus aureus MRSA252 in vitro, and of MRSA252 and ATCC 25923 bacteria in an ex vivo pig skin model using 1 × 1 cm square matrices containing tetracycline (30 μg). Human FEK4 cells grew normally in the presence of these matrices.
conclusionsThe ability of the zein-based matrices to destroy bacteria within increasingly complex in vitro biofilm models was clearly established. An ex vivo pig skin assay showed that these matrices, with entrapped tetracycline, efficiently kill bacteria and this, combined with their compatibility with a human skin cell line suggest these matrices are well suited for applications in wound healing and infection control.
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