Evidence map›Paper›PMID 26337692›Full record

ArticleObesity surgery2016

Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients.

Stefania Mariani, Daniela Fiore, Agnese Persichetti, Sabrina Basciani, Carla Lubrano, Eleonora Poggiogalle, Alfredo Genco, Lorenzo Maria Donini, Lucio Gnessi

Abstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Intragastric Balloon Placement Induces Significant Metabolic and Histologic Improvement in Patients With Nonalcoholic Steatohepatitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. The Sirtuin Network: Linking NADDiabetes/metabolism research and reviews · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. SIRT1 Serum Concentrations in Lipodystrophic Syndromes.International journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Stefania MarianiDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy. stefaniamariani@yahoo.com.
Daniela FioreDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Agnese PersichettiDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Sabrina BascianiDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Carla LubranoDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Eleonora PoggiogalleDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Alfredo GencoDepartment of Surgical Sciences, Surgical Endoscopy Unit, Sapienza University of Rome, Rome, Italy.
Lorenzo Maria DoniniDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Lucio GnessiDepartment of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSirtuins (SIRTs), ubiquitous deacetylases, are main regulators of energy homeostasis and metabolism. SIRT1 has a positive impact on obesity, diabetes mellitus, liver steatosis, and other metabolic disorders. Lean subjects have higher expression of SIRT1 in the adipose tissue compared to obese. However, it is not known whether weight loss associates with changes in blood SIRT1. We evaluated the effect of weight loss on circulating SIRT1, metabolic parameters, and body composition.

methodsThirty-two obese subjects were studied before and 6 months after BioEnterics® Intragastric Balloon (BIB®) [22 patients, BMI 41.82 ± 6.28 kg/m(2)] or hypocaloric diet [10 patients, BMI 38.95 ± 6.90 kg/m(2)]. Plasma SIRT1, body composition, measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, HDL cholesterol, triglycerides), and inflammation markers (ESR, CRP, fibrinogen) were recorded.

resultsSIRT1 levels showed a significant increase, together with a significant reduction of BMI, excess body weight, and total fat mass either after BIB or diet intervention. The percent excess body weight loss was 33.73 ± 19.06 and 22.08 ± 11.62 % after BIB and diet, respectively, a trend toward a metabolic and inflammatory amelioration was observed with both treatments. Negative correlation between SIRT1 and % fat mass (BIB, ρ = -0.537, p = 0.017; diet, ρ = -0.638, p = 0.047) was also seen.

conclusionsThe reduction of fat mass associates with increased plasma SIRT1 indicating that, besides tissue levels, circulating SIRT1 is stimulated by a negative caloric balance. The rise of plasma SIRT1 may represent a parameter associating with fat loss rather than weight lowering regardless of the weight reduction system method used.

Indexed as

Weight LossAdolescentAdultBody CompositionDiet, ReducingFemaleGastric BalloonHumansMaleMiddle AgedObesityPostoperative PeriodSirtuin 1TriglyceridesYoung AdultSIRT1 protein, humanSirtuin 1TriglyceridesBIBFat massObesitySIRT1Weight loss

Identifiers

PMID26337692
OpenAlexW1241013975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.