SynthesisJournal of medical genetics2015
Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.
Synthesis in Journal of medical genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank.EBioMedicine · 2020Pooled it
- Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.Journal of foot and ankle research · 2020Pooled it
- Early initiation of zoledronic acid does not impact bone healing or clinical outcomes of hallux valgus orthomorphia.The Journal of international medical research · 2018Trial
- Predictors and Prevention of Hallux Valgus Recurrence After Primary Surgical Correction: A Structured Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Combining Mendelian Randomization and Experimental Validation to Reveal the Causal Relationship Between Hallux Valgus and Serum Metabolites and to Identify Their Therapeutic Targets and Relevant Components.Food science & nutrition · 2026Article
- Prevalence and Severity of Self-Assessed Hallux Valgus in Community-Dwelling Older South African and Flemish Individuals.Journal of foot and ankle research · 2026Observational
- Anatomical Study of the Tibialis Posterior Tendon's Connections to the Plantar Muscles and Its Relationship With the Severity of Hallux Valgus.Journal of foot and ankle research · 2025Article
- The efficacy of shoes modification and orthotics in hallux valgus deformity: a comprehensive review of literature.Musculoskeletal surgery · 2024Review
- Identification of copy number variants contributing to hallux valgus.Frontiers in genetics · 2023Article
- New insights into hallux valgus by whole exome sequencing study.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- The influence of obesity and gender on outcome after reversed L-shaped osteotomy for hallux valgus.BMC musculoskeletal disorders · 2019Article
- Breastfeeding Support Offered at Delivery is Associated with Higher Prevalence of Exclusive Breastfeeding at 6 Weeks Postpartum Among HIV Exposed Infants: A Cross-Sectional Analysis.Maternal and child health journal · 2019Article
- The influence of the number of screws and additional surgical procedures on outcome in hallux valgus treatment.Journal of orthopaedic surgery and research · 2018Article
- Epidemiology of Shoe Wearing Patterns Over Time in Older Women: Associations With Foot Pain and Hallux Valgus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Impact of Vitamin D Receptor Genotypes on Taiwan Hallux Valgus.In vivo (Athens, Greece)Article
- Impacts of Methylenetetrahydrofolate Reductase Genotypes on Hallux Valgus.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveHallux valgus (HV) affects ∼36% of Caucasian adults. Although considered highly heritable, the underlying genetic determinants are unclear. We conducted the first genome-wide association study (GWAS) aimed to identify genetic variants associated with HV.
methodsHV was assessed in three Caucasian cohorts (n=2263, n=915 and n=1231 participants, respectively). In each cohort, a GWAS was conducted using 2.5 M imputed SNPs. Mixed-effect regression with the additive genetic model adjusted for age, sex, weight and within-family correlations was used for both sex-specific and combined analyses. To combine GWAS results across cohorts, fixed-effect inverse-variance meta-analyses were used. Following meta-analyses, top-associated findings were also examined in an African American cohort (n=327).
resultsThe proportion of HV variance explained by genome-wide genotyped SNPs was 50% in men and 48% in women. A higher proportion of genetic determinants of HV were sex specific. The most significantly associated SNP in men was rs9675316 located on chr17q23-a24 near the AXIN2 gene (p=0.000000546×10(-7)); the most significantly associated SNP in women was rs7996797 located on chr13q14.1-q14.2 near the ESD gene (p=0.000000721×10(-7)). Genome-wide significant SNP-by-sex interaction was found for SNP rs1563374 located on chr11p15.1 near the MRGPRX3 gene (interaction p value =0.0000000041×10(-9)). The association signals diminished when combining men and women.
conclusionsThe findings suggest that the potential pathophysiological mechanisms of HV are complex and strongly underlined by sex-specific interactions. The identified genetic variants imply contribution of biological pathways observed in osteoarthritis as well as new pathways, influencing skeletal development and inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.