ArticleJournal of nanobiotechnology2015
The influence of the size and aspect ratio of anisotropic, porous CaCO3 particles on their uptake by cells.
Article in Journal of nanobiotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 165 citations in OpenAlex.
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- Elongated Particles Show a Preferential Uptake in Invasive Cancer Cells.Nanomaterials (Basel, Switzerland) · 2024Article
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- Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.Frontiers in bioengineering and biotechnology · 2024Article
- Microfluidically Assisted Synthesis of Calcium Carbonate Submicron Particles with Improved Loading Properties.Micromachines · 2023Article
- Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents.Nanomaterials (Basel, Switzerland) · 2023Article
- Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology.Bioactive materials · 2023Article
- Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study.Beilstein journal of nanotechnology · 2023Article
- Activation of Neutrophils by Mucin-Vaterite Microparticles.International journal of molecular sciences · 2022Article
- Hard, Soft, and Hard-Pharmaceutics · 2022Review
- Influence of the chirality of carbon nanodots on their interaction with proteins and cells.Nature communications · 2021Article
- Requirements for Designing an Effective Metallic Nanoparticle (NP)-Boosted Radiation Therapy (RT).Cancers · 2021Review
- Post-synthesis nanostructuration of BSA-Capsaicin nanoparticles generated by sucrose excipient.Scientific reports · 2021Article
- Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems.Antioxidants (Basel, Switzerland) · 2021Review
- Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCOMaterials (Basel, Switzerland) · 2021Article
- Development of Silica-Based Biodegradable Submicrometric Carriers and Investigating Their Characteristics as in Vitro Delivery Vehicles.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports highlighting the role of particle geometry have suggested that anisotropy can affect the rate and the pathway of particle uptake by cells. Therefore, we investigate the internalization by cells of porous calcium carbonate particles with different shapes and anisotropies.
resultsWe report here on a new method of the synthesis of polyelectrolyte coated calcium carbonate particles whose geometry was controlled by varying the mixing speed and time, pH value of the reaction solution, and ratio of the interacting salts used for particle formation. Uptake of spherical, cuboidal, ellipsoidal (with two different sizes) polyelectrolyte coated calcium carbonate particles was studied in cervical carcinoma cells. Quantitative data were obtained from the analysis of confocal laser scanning microscopy images.
conclusionsOur results indicate that the number of internalized calcium carbonate particles depends on the aspect ratio of the particle, whereby elongated particles (higher aspect ratio) are internalized with a higher frequency than more spherical particles (lower aspect ratio). The total volume of internalized particles scales with the volume of the individual particles, in case equal amount of particles were added per cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.