Evidence map›Paper›PMID 26337431›Full record

ArticleEuropean radiology2016

Strain ratio ultrasound elastography increases the accuracy of colour-Doppler ultrasound in the evaluation of Thy-3 nodules. A bi-centre university experience.

Vito Cantisani, Piero Maceroni, Vito D'Andrea, Gregorio Patrizi, Mattia Di Segni, Corrado De Vito, Hektor Grazhdani, Andrea M Isidori, Elisa Giannetta, Adriano Redler and 5 more

Abstract readEvaluation StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  7. Thyroid ultrasound and its ancillary techniques.Reviews in endocrine & metabolic disorders · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vito CantisaniDepartment of Radiology, Anatomical Pathology and Oncology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy. vito.cantisani@uniroma1.it.
Piero MaceroniDepartment of Diagnostic Imaging for Surgery, Orthopaedics and Traumatology, "Sapienza" University of Rome, Rome, Italy.
Vito D'AndreaDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Gregorio PatriziDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Mattia Di SegniDepartment of Radiology, Anatomical Pathology and Oncology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Corrado De VitoDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
Hektor GrazhdaniDepartment of Radiology, Anatomical Pathology and Oncology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Elisa GiannettaDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Adriano RedlerDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Fabrizio FrattaroliDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Laura GiacomelliDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Giorgio Di RoccoDepartment of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiology, Anatomical Pathology and Oncology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Ferdinando D'AmbrosioDepartment of Radiology, Anatomical Pathology and Oncology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess whether ultrasound elastography (USE) with strain ratio increases diagnostic accuracy of Doppler ultrasound in further characterisation of cytologically Thy3 thyroid nodules.

methodsIn two different university diagnostic centres, 315 patients with indeterminate cytology (Thy3) in thyroid nodules aspirates were prospectively evaluated with Doppler ultrasound and strain ratio USE before surgery. Ultrasonographic features were analysed separately and together as ultrasound score, to assess sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Receiver operating characteristic (ROC) curves to identify optimal cut-off value of the strain ratio were also provided. Diagnosis on a surgical specimen was considered the standard of reference.

resultsHigher strain ratio values were found in malignant nodules, with an optimum strain ratio cut-off of 2.09 at ROC analysis. USE with strain ratio showed 90.6% sensitivity, 93% specificity, 82.8% PPV, 96.4% NPV, while US score yielded a sensitivity of 52.9%, specificity of 84.3%, PPV 55.6% and NPV 82.9%. The diagnostic gain with strain ratio was statistically significant as proved by ROC areas, which was 0.9182 for strain ratio and 0.6864 for US score.

conclusionsUSE with strain ratio should be considered a useful additional tool to colour-Doppler US, since it improves characterisation of thyroid nodules with indeterminate cytology. KEY POINTS: • Strain ratio measurements improve differentiation of thyroid nodules with indeterminate cytology • Elastography with strain ratio is more reliable than ultrasound features and ultrasound score • Strain ratio may help to better select patients with Thy 3 nodules candidate for surgery.

Indexed as

AdolescentAdultAgedAged, 80 and overElasticity Imaging TechniquesFemaleHumansMaleMiddle AgedProspective StudiesROC CurveSensitivity and SpecificityThyroid NoduleUltrasonography, Doppler, ColorYoung AdultIndeterminate cytologyStrain ratioThy3 thyroid nodulesUltrasoundUltrasound strain elastography

Identifiers

PMID26337431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.