ArticleScientific reports2015
The motility-proliferation-metabolism interplay during metastatic invasion.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Stable overexpression of the epithelial sodium channel alpha subunit reduces migration and proliferation in breast cancer cells.Breast cancer research and treatment · 2025Article
- Cancer metastasis: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2025Review
- Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect.Science advances · 2023Article
- Differentiation-related epigenomic changes define clinically distinct keratinocyte cancer subclasses.Molecular systems biology · 2022Article
- The molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy.Translational oncology · 2022Review
- Imaging developmental cell cycles.Biophysical journal · 2021Review
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- Mechanoresponsive metabolism in cancer cell migration and metastasis.Cell metabolism · 2021Review
- 5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Identification and development of a novel invasion-related gene signature for prognosis prediction in colon adenocarcinoma.Cancer cell international · 2021Article
- Effect of the Expression ofFrontiers in genetics · 2021Article
- ROCK1-PredictedmicroRNAs Dysregulation Contributes to Tumor Progression in Ewing Sarcoma.Pathology oncology research : POR · 2020Article
- 5-HTOncoTargets and therapy · 2020Article
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- A DSTYK mutation activates ERK1/2 signaling to promote intraspinal dissemination in a case of solitary fibrous tumor/hemangiopericytoma.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making.Nature communications · 2019Article
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- SUN2: A potential therapeutic target in cancer.Oncology letters · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis is the major cause for cancer patients' death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that are involved in the migration of the cells in a complex environment is a key step towards successful anti-metastatic treatment. Using experimental data-based modeling, we focus on the fundamentals of metastatic invasion: motility, invasion, proliferation and metabolism, and study how they may be combined to maximize the cancer's ability to metastasize. The modeled cells' performance is measured by the number of cells that succeed in migration in a maze, which mimics the extracellular environment. We show that co-existence of different cell clones in the tumor, as often found in experiments, optimizes the invasive ability in a frequently-changing environment. We study the role of metabolism and stimulation by growth factors, and show that metabolism plays a crucial role in the metastatic process and should therefore be targeted for successful treatment.
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