Evidence map›Paper›PMID 26337160›Full record

ArticleJournal of cancer research and clinical oncology2016

The risk of female malignancies after fertility treatments: a cohort study with 25-year follow-up.

R Kessous, E Davidson, M Meirovitz, R Sergienko, E Sheiner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  11. Epidemiological trends and risk factors of gynecological cancers: an update.Medical oncology (Northwood, London, England) · 2023
    Review
  12. Article
  13. Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status.Journal of assisted reproduction and genetics · 2020 · on this map
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Use of fertility medications and cancer risk: a review and update.Current opinion in obstetrics & gynecology · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

R KessousDepartment of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, 84101, Beersheba, Israel. kessousr@bgu.ac.il.
E DavidsonFaculty of Health Sciences, Soroka University Medical Center, Clalit Health Services (Southern District), Ben-Gurion University of the Negev, Beersheba, Israel.
M MeirovitzDepartment of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, 84101, Beersheba, Israel.
R SergienkoDepartment of Public Health, Ben-Gurion University of the Negev, Beersheba, Israel.
E SheinerDepartment of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, 84101, Beersheba, Israel. sheiner@bgu.ac.il.
Ben-Gurion University of the Negev · ILClalit Health Services · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY

designA population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vitro fertilization (IVF) and ovulation induction (OI). Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12 years. Excluded from the study were women with known genetic predisposition for malignancies or known malignancies prior to the index pregnancy. Female malignancies were divided into specific types including ovarian, uterine, breast and cervix. Kaplan-Meier survival curve was used to estimate cumulative incidence of malignancies. Cox proportional hazard models were used to estimate the adjusted hazard ratios (HRs) for female malignancy.

resultsDuring the study period, 106,031 women met the inclusion criteria; 4.1 % (n = 4363) occurred in patients following fertility treatments. During the follow-up period, patients with a history of IVF treatments had a significantly increased risk of being diagnosed with ovarian and uterine cancer as compared to patients after OI and patients with no history of fertility treatments. Cox proportional hazard models were constructed for ovarian and uterine cancer separately, controlling for confounders such as maternal age and obesity. A history of IVF treatment remained independently associated with ovarian and uterine cancer (adjusted HR 3.9; 95 % CI 1.2-12.6; P = 0.022 and adjusted HR 4.6; 95 % CI 1.4-14.9; P = 0.011; respectively).

conclusionIVF treatments pose a significant risk of subsequent long-term ovarian and uterine cancer.

Indexed as

AdultBreast NeoplasmsCohort StudiesFemaleFertilityFertility Agents, FemaleFertilization in VitroFollow-Up StudiesGenital Neoplasms, FemaleHospitalizationHumansIsraelNeoplasm StagingOvulation InductionPregnancyPrevalenceFertility Agents, FemaleFemale malignanciesIn vitro fertilizationOvarian cancerOvulation inductionUterine cancer

Identifiers

PMID26337160
PMCPMC11819006
OpenAlexW1799526768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.