SynthesisEpilepsia2015
Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases.
Synthesis in Epilepsia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- The Effectiveness and Safety of Hormonal Combinations of Antiepileptic Drugs in the Treatment of Epileptic Electrical Continuity in Children during Sleep: A Meta-Analysis.Computational intelligence and neuroscience · 2022Pooled it
- Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep: Pathophysiological insights and treatment options.Epilepsia · 2026Review
- Developmental and/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep: From Thalamocortical Mechanisms to Precision Therapy.Children (Basel, Switzerland) · 2026Review
- Cognitive impairments and neurofunctional alterations in children with electrical status epilepticus during sleep: insights from WISC-IV and resting-state fMRI.BMC medicine · 2026Article
- Epilepsy in Chinese Children With Mowat-Wilson Syndrome: Two Case Reports and Literature Review.Journal of paediatrics and child health · 2026Article
- Surgical Treatment of Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep Associated with Polymicrogyria: A Case Report.Stereotactic and functional neurosurgery · 2026Article
- Observational
- Rebuilding the Tower of Babel: The Current Landscape and Emerging Opportunities in DEE-SWAS.Epilepsy currents · 2025Review
- European experience of steroid therapy in children with developmental and epileptic encephalopathy with spike wave activation in sleep ((D)EE-SWAS).Orphanet journal of rare diseases · 2025Article
- Motor Outcome After Posterior Insular Resection for Pediatric Epilepsy.Brain sciences · 2025Article
- Vagus nerve stimulation for spike-and-wave activation in sleep in a pediatric patient: a case report.Frontiers in neuroscience · 2025Article
- Predicting progression from SeLECTS with SWAS to EE-SWAS: risk factor identification and model development.Frontiers in human neuroscience · 2025Article
- Multiple Subpial Transection for the Treatment of Landau-Kleffner Syndrome-Review of the Literature.Journal of clinical medicine · 2024Review
- Pulsatile corticoid therapy reduces interictal epileptic activity burden in children with genetic drug-resistant epilepsy.Epilepsia open · 2024Article
- Mutation in the GRIA4 Gene Presenting as ESES: Expanding the Genetic Landscape of ESES.Annals of Indian Academy of Neurology · 2024Article
- Efficacy and Safety of Pulse Intravenous Methylprednisolone in Pediatric Epileptic Encephalopathies: Timing and Networks Consideration.Journal of clinical medicine · 2024Article
- Continuous Spike-Waves during Slow Sleep Today: An Update.Children (Basel, Switzerland) · 2024Review
- Successful treatment of epileptic encephalopathy with spike wave activation in sleep with anakinra.Epilepsy & behavior reports · 2024Article
- Electrical Status Epilepticus during Sleep in a Male Filipino with Rare Nonsense Mutation Variant of Sotos Syndrome on Carbamazepine Monotherapy.Acta medica Philippina · 2024Article
- Exploratory analysis of high-dose corticosteroid therapy on epileptic encephalopathy with spike-and-wave activation in sleep.Frontiers in pediatrics · 2024Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpileptic encephalopathy with electrical status epilepticus in sleep (ESES) is a pediatric epilepsy syndrome with sleep-induced epileptic discharges and acquired impairment of cognition or behavior. Treatment of ESES is assumed to improve cognitive outcome. The aim of this study is to create an overview of the current evidence for different treatment regimens in children with ESES syndrome.
methodsA literature search using PubMed and Embase was performed. Articles were selected that contain original treatment data of patients with ESES syndrome. Authors were contacted for additional information. Individual patient data were collected, coded, and analyzed using logistic regression analysis. The three predefined main outcome measures were improvement in cognitive function, electroencephalography (EEG) pattern, and any improvement (cognition or EEG).
resultsThe literature search yielded 1,766 articles. After applying inclusion and exclusion criteria, 112 articles and 950 treatments in 575 patients could be analyzed. Antiepileptic drugs (AEDs, n = 495) were associated with improvement (i.e., cognition or EEG) in 49% of patients, benzodiazepines (n = 171) in 68%, and steroids (n = 166) in 81%. Surgery (n = 62) resulted in improvement in 90% of patients. In a subgroup analysis of patients who were consecutively reported (585 treatments in 282 patients), we found improvement in a smaller proportion treated with AEDs (34%), benzodiazepines (59%), and steroids (75%), whereas the improvement percentage after surgery was preserved (93%). Possible predictors of improved outcome were treatment category, normal development before ESES onset, and the absence of structural abnormalities. SIGNIFICANCE: Although most included studies were small and retrospective and their heterogeneity allowed analysis of only qualitative outcome data, this pooled analysis suggests superior efficacy of steroids and surgery in encephalopathy with ESES.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.