ArticleEpilepsia2015
Cognition and brain development in children with benign epilepsy with centrotemporal spikes.
Article in Epilepsia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Anti-Seizure Medication Treatment of Benign Childhood Epilepsy With Centrotemporal Spikes: A Systematic Review and Meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Neurodevelopmental origins of self-limiting rolandic epilepsy: Systematic review of MR imaging studies.Epilepsia open · 2021Pooled it
- Safety and efficacy of one-dose nocturnal levetiracetam for the treatment of self-limited epilepsy with centrotemporal spikes: a randomized clinical trial.Scientific reports · 2025Trial
- Nightly oral administration of topiramate for benign childhood epilepsy with centrotemporal spikes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Trial
- Shared Genetic Architecture Between Common Epilepsies and Subcortical Brain Volumes Is Associated With Cognition and Mental Health.CNS neuroscience & therapeutics · 2026Article
- Functional connectivity in self-limited epilepsy with centrotemporal spikes increases with epilepsy duration and interictal spike exposure.Epilepsia · 2026Article
- Executive functions and self-limited epilepsy with centro-temporal spikes: A scoping review.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Linking Cortical Morphometry in Self-Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture.CNS neuroscience & therapeutics · 2026Article
- Elevated Thalamic Blood Flow in Self-Limited Epilepsy with Centrotemporal Spikes.bioRxiv : the preprint server for biology · 2025Article
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
- The relationship between neuromagnetic networks and cognitive impairment in self-limited epilepsy with centrotemporal spikes.Epilepsia open · 2025Article
- Predicting progression from SeLECTS with SWAS to EE-SWAS: risk factor identification and model development.Frontiers in human neuroscience · 2025Article
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- Brain structural changes and molecular analyses in children with benign epilepsy with centrotemporal spikes.Pediatric research · 2024Article
- Enhancing Executive Functions in Pediatric Epilepsy: Feasibility and Efficacy of a Computerized Cognitive Training Program.Children (Basel, Switzerland) · 2024Article
- Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes.Japanese journal of radiology · 2023Article
- Atypical functional connectivity hierarchy in Rolandic epilepsy.Communications biology · 2023Article
- Children with Rolandic epilepsy have micro- and macrostructural abnormalities in white matter constituting networks necessary for language function.Epilepsy & behavior : E&B · 2023Article
- Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review.Current neuropharmacology · 2023Review
- Brain magnetic resonance imaging findings and brain volumetric differences in a large series of benign rolandic epilepsy.The neuroradiology journal · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBenign epilepsy with centrotemporal spikes (BECTS), the most common focal childhood epilepsy, is associated with subtle abnormalities in cognition and possible developmental alterations in brain structure when compared to healthy participants, as indicated by previous cross-sectional studies. To examine the natural history of BECTS, we investigated cognition, cortical thickness, and subcortical volumes in children with new/recent onset BECTS and healthy controls (HC).
methodsParticipants were 8-15 years of age, including 24 children with new-onset BECTS and 41 age- and gender-matched HC. At baseline and 2 years later, all participants completed a cognitive assessment, and a subset (13 BECTS, 24 HC) underwent T1 volumetric magnetic resonance imaging (MRI) scans focusing on cortical thickness and subcortical volumes.
resultsBaseline cognitive abnormalities associated with BECTS (object naming, verbal learning, arithmetic computation, and psychomotor speed/dexterity) persisted over 2 years, with the rate of cognitive development paralleling that of HC. Baseline neuroimaging revealed thinner cortex in BECTS compared to controls in frontal, temporal, and occipital regions. Longitudinally, HC showed widespread cortical thinning in both hemispheres, whereas BECTS participants showed sparse regions of both cortical thinning and thickening. Analyses of subcortical volumes showed larger left and right putamens persisting over 2 years in BECTS compared to HC. SIGNIFICANCE: Cognitive and structural brain abnormalities associated with BECTS are present at onset and persist (cognition) and/or evolve (brain structure) over time. Atypical maturation of cortical thickness antecedent to BECTS onset results in early identified abnormalities that continue to develop abnormally over time. However, compared to anatomic development, cognition appears more resistant to further change over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.