ArticleOphthalmology2015
Human Papilloma Virus Infection Does Not Predict Response to Interferon Therapy in Ocular Surface Squamous Neoplasia.
Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- HPV-positive cancers at uncommon sites: a narrative review.Oncology reviews · 2026Review
- Infectious etiologies of conjunctival tumors.Expert review of ophthalmology · 2025Article
- High-risk human papillomavirus-associated corneal/conjunctival intraepithelial neoplasia in a young patient.American journal of ophthalmology case reports · 2023Article
- Detection of Human Papillomavirus in Squamous Lesions of the Conjunctiva Using RNA and DNA In-Situ Hybridization.International journal of molecular sciences · 2022Article
- Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients.Frontiers in oncology · 2022Article
- Ocular surface squamous neoplasia: management and outcomes.Eye (London, England) · 2021Review
- Cost-effective treatment of ocular surface squamous neoplasia for an undocumented and uninsured New York City patient: a case report.Journal of medical case reports · 2020Article
- Epidemiology of ocular surface squamous neoplasia in veterans: a retrospective case-control study.Eye and vision (London, England) · 2019Article
- Clinical Management of Ocular Surface Squamous Neoplasia: A Review of the Current Evidence.Ophthalmology and therapy · 2018Review
- Human papillomavirus (HPV)-associated trilateral squamous neoplasia in immunocompetent individual.International ophthalmology · 2018Article
- Papilloma and sebaceous gland hyperplasia of the lacrimal caruncle: a case report.International medical case reports journal · 2018Article
- Human Papilloma Virus Vaccination and Incidence of Ocular Surface Squamous Neoplasia.International ophthalmology clinics · 2017Review
- Diagnosis and Medical Management of Ocular Surface Squamous Neoplasia.Expert review of ophthalmology · 2017Article
- Recombinant interferon alpha 2b for ocular surface squamous neoplasia: An efficient and cost-effective treatment modality in Asian Indian patients.Indian journal of ophthalmology · 2016Article
- Recombinant Interferon Alpha-2b as Primary Treatment for Ocular Surface Squamous Neoplasia.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo identify the frequency of human papilloma virus (HPV) in ocular surface squamous neoplasia (OSSN) and to evaluate differences in clinical features and treatment response of tumors with positive versus negative HPV results.
designRetrospective case series.
participantsTwenty-seven patients with OSSN.
methodsOcular surface squamous neoplasia specimens were analyzed for the presence of HPV. Clinical features and response to interferon were determined retrospectively and linked to the presence (versus absence) of HPV.
main outcome measuresClinical characteristics of OSSN by HPV status.
resultsTwenty-one of 27 tumors (78%) demonstrated positive HPV results. The HPV genotypes identified included HPV-16 in 10 tumors (48%), HPV-31 in 5 tumors, HPV-33 in 1 tumor, HPV-35 in 2 tumors, HPV-51 in 2 tumors, and a novel HPV in 3 tumors (total of 23 tumors because 1 tumor had 3 identified genotypes). Tumors found in the superior limbus were more likely to show positive HPV results (48% vs. 0%; P=0.06, Fisher exact test). Tumors with positive HPV-16 results were larger (68 vs. 34 mm2; P=0.08, Mann-Whitney U test) and were more likely to have papillomatous morphologic features (50% vs. 12%; P=0.07, Fisher exact test) compared with tumors showing negative results for HPV-16. Human papilloma virus status was not found to be associated with response to interferon therapy (P=1.0, Fisher exact test). Metrics found to be associated with a nonfavorable response to interferon were male gender and tumors located in the superior conjunctivae.
conclusionsThe presence of HPV in OSSN seems to be more common in lesions located in the nonexposed, superior limbus. Human papilloma virus presence does not seem to be required for a favorable response to interferon therapy.
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Registered trials
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