Evidence map›Paper›PMID 26336989›Full record

ArticleOncotarget2015

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4.

Tae Heung Kang, Young Seob Kim, Seokho Kim, Benjamin Yang, Je-Jung Lee, Hyun-Ju Lee, Jaemin Lee, In Duk Jung, Hee Dong Han, Seung-Hyun Lee and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Tae Heung KangDepartment of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Young Seob KimDepartment of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Seokho KimAging Research Institute, Korea Research Institute of Bioscience & Biotechnology, Daejeon, South Korea.
Benjamin YangDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Je-Jung LeeResearch Center for Cancer Immunotherapy, Hwasun Hospital, Chonnam National University, Hwasun, Jeollanamdo, South Korea.
Hyun-Ju LeeResearch Center for Cancer Immunotherapy, Hwasun Hospital, Chonnam National University, Hwasun, Jeollanamdo, South Korea.
Jaemin LeeAging Research Institute, Korea Research Institute of Bioscience & Biotechnology, Daejeon, South Korea.
In Duk JungDepartment of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Hee Dong HanDepartment of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Seung-Hyun LeeDepartment of Microbiology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Sang Seok KohDepartment of Biological Sciences, Dong-A University, Busan, South Korea.
T-C WuDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Yeong-Min ParkDepartment of Immunology, KU Open Innovation Center, School of Medicine, Konkuk University, Chungju, South Korea.
Konkuk University · KRChonnam National University Hwasun Hospital · KRJohns Hopkins University · USKorea Research Institute of Bioscience and Biotechnology · KRDong-A University · KR

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
NCI NIH HHS P50 CA098252NCI NIH HHS P50CA098252
6 · The paper itself

Abstract

Dendritic cell (DC) based cancer vaccines represent a promising immunotherapeutic strategy against cancer. To enhance the modest immunogenicity of DC vaccines, various adjuvants are often incorporated. Particularly, most of the common adjuvants are derived from bacteria. In the current study, we evaluate the use of a human pancreatic cancer derived protein, pancreatic adenocarcinoma upregulated factor (PAUF), as a novel DC vaccine adjuvant. We show that PAUF can induce activation and maturation of DCs and activate NFkB by stimulating the Toll-like receptor signaling pathway. Furthermore, vaccination with PAUF treated DCs pulsed with E7 or OVA peptides leads to generation of E7 or OVA-specific CD8+ T cells and memory T cells, which correlate with long term tumor protection and antitumor effects against TC-1 and EG.7 tumors in mice. Finally, we demonstrated that PAUF mediated DC activation and immune stimulation are dependent on TLR4. Our data provides evidence supporting PAUF as a promising adjuvant for DC based therapies, which can be applied in conjunction with other cancer therapies. Most importantly, our results serve as a reference for future investigation of human based adjuvants.

Indexed as

AdenocarcinomaAdjuvants, ImmunologicAnimalsCancer VaccinesCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsFemaleFlow CytometryHumansImmunologic MemoryIntercellular Signaling Peptides and ProteinsLectinsMiceMice, Inbred C57BLMice, KnockoutAdjuvants, ImmunologicCancer VaccinesIntercellular Signaling Peptides and ProteinsLectinsNF-kappa B p50 SubunitNFKB1 protein, humanNfkb1 protein, mouseoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsPeptidesTLR4 protein, humanTlr4 protein, mouseToll-Like Receptor 4ZG16B protein, humanadjuvantscancer vaccinesdendritic cellsPAUFTLR4

Identifiers

PMID26336989
PMCPMC4695023
OpenAlexW1750334743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.