Evidence map›Paper›PMID 26336641›Full record

ArticlePeerJ2015

Orthostatic stability with intravenous levodopa.

Shan H Siddiqi, Mary L Creech, Kevin J Black

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00634556 (Dopaminergic Effects on Cortical Function in Tourette's), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00634556 phase1completednot on this map

Dopaminergic Effects on Cortical Function in Tourette's (Levodopa Protocol)

TypeinterventionalSponsorWashington University School of MedicineRan2006 to 2010Enrolled49ConditionsTourette SyndromeArmslevodopa solution 2mg/ml for i.v. use, placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The Human Experience with Intravenous Levodopa.Frontiers in pharmacology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shan H SiddiqiDepartment of Psychiatry, Washington University School of Medicine , St. Louis, MO , USA.
Mary L CreechDepartment of Neurology, Washington University School of Medicine , St. Louis, MO , USA.
Kevin J BlackDepartment of Psychiatry, Washington University School of Medicine , St. Louis, MO , USA ; Department of Neurology, Washington University School of Medicine , St. Louis, MO , USA ; Department of Radiology, Anatomy & Neurobiology, and Division of Biology and Biomedical Sciences, Washington University School of Medicine , St. Louis, MO , USA.
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI NEWCOMER, JOHN W. · 1985 to 2007
$25.4M
Washington University Center for Translational NeuroscienceP30NS057105 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2006 to 2011
$8.7M
Dopaminergic Effects on Cortical Function in Tourette'sR01MH073856 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2006 to 2010
$1.9M
RES FACIL CONST: NEUROSCIENCE: LANGUAGE, COGNITION &BEHAVIOR, PAIN, DEPRESSIONC06RR020092 · NCRR · WASHINGTON UNIVERSITY · PI CICERO, THEODORE J · 2004 to 2004
$1.6M
Training New Investigators in Neuroimaging and in the Neuropsychiatry of MovementK24MH087913 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2010 to 2014
$818k
NCATS NIH HHS UL1 TR000448NCRR NIH HHS C06 RR020092NCRR NIH HHS M01 RR000036NCRR NIH HHS UL1 RR024992NIMH NIH HHS K24 MH087913NIMH NIH HHS R01 MH073856NINDS NIH HHS P30 NS057105
6 · The paper itself

Abstract

Intravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson's disease (PD). Levodopa is the precursor for dopamine, and intravenous dopamine would strongly affect vascular tone, but peripheral decarboxylase inhibitors are intended to block such effects. Pulse and blood pressure, with orthostatic changes, were recorded before and after intravenous levodopa or placebo-after oral carbidopa-in 13 adults with a chronic tic disorder and 16 tic-free adult control subjects. Levodopa caused no statistically or clinically significant changes in blood pressure or pulse. These data add to previous data that support the safety of i.v. levodopa when given with adequate peripheral inhibition of DOPA decarboxylase.

Indexed as

Blood pressureCarbidopaHeart rateIntravenousLevodopaRandomized controlled trialTourette syndrome

Identifiers

PMID26336641
PMCPMC4556150
OpenAlexW1861539431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.