ArticleBMJ open diabetes research & care2015
A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities.
Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01131052 (Diabetes Care in Nursing Home Residents), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diabetes Care in Nursing Home Residents: A Randomized Controlled Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019Guideline
- Efficacy of telemedicine on glycaemic control in nursing home residents with type 2 diabetes on basal-bolus insulin therapy: A randomised controlled trial.Diabetes, obesity & metabolism · 2026Trial
- Continuous Glucose Monitoring-Guided Insulin Administration in Long-Term Care Facilities: A Randomized Clinical Trial.Journal of the American Medical Directors Association · 2024Trial
- THE EFFICACY AND SAFETY OF CO-ADMINISTRATION OF SITAGLIPTIN WITH METFORMIN IN PATIENTS WITH TYPE 2 DIABETES AT HOSPITAL DISCHARGE.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2018Trial
- A Randomized Controlled Study Comparing a DPP4 Inhibitor (Linagliptin) and Basal Insulin (Glargine) in Patients With Type 2 Diabetes in Long-term Care and Skilled Nursing Facilities: Linagliptin-LTC Trial.Journal of the American Medical Directors Association · 2018Trial
- 13. Older Adults: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Agreement Between Fingerstick Blood Glucose and Continuous Glucose Monitor Measures Among Long-Term Care Facility Residents.Journal of the American Geriatrics Society · 2025Observational
- Impact of treatment modality on cognition in older adults with type 2 diabetes mellitus.Journal of family medicine and primary care · 2025Article
- Managing Diabetes in Older Adults: Current Approaches in Long-Term Care Facilities.Current diabetes reports · 2025Review
- Re-starting or initiating guideline-recommended hypoglycemic agents for patients admitted with hyperglycemic crisis.Frontiers in medicine · 2025Article
- 13. Older Adults: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Tertiary centre study highlights low inpatient deintensification and risks associated with adverse outcomes in frail people with diabetes.Clinical medicine (London, England) · 2024Article
- 13. Older Adults: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register.Internal and emergency medicine · 2023Article
- Gaps in our knowledge of managing inpatient dysglycaemia and diabetes in non-critically ill adults: A call for further research.Diabetic medicine : a journal of the British Diabetic Association · 2023Review
- 13. Older Adults: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Effect of Health Literacy Intervention on Glycemic Control and Renal Function Among Thai Older Adults at Risk of Type 2 Diabetes Mellitus.Clinical interventions in aging · 2023Article
- Update on the management of diabetes in long-term care facilities.BMJ open diabetes research & care · 2022Review
- Management of Hyperglycemia in Older Adults with Type 2 Diabetes.Drugs & aging · 2022Review
- 13. Older Adults: Standards of Medical Care in Diabetes-2022.Diabetes care · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundManaging hyperglycemia and diabetes is challenging in geriatric patients admitted to long-term care (LTC) facilities.
methodsThis randomized control trial enrolled patients with type 2 diabetes (T2D) with blood glucose (BG) >180 mg/dL or glycated hemoglobin >7.5% to receive low-dose basal insulin (glargine, starting dose 0.1 U/kg/day) or oral antidiabetic drug (OAD) therapy as per primary care provider discretion for 26 weeks. Both groups received supplemental rapid-acting insulin before meals for BG >200 mg/dL. Primary end point was difference in glycemic control as measured by fasting and mean daily glucose concentration between groups.
resultsA total of 150 patients (age: 79±8 years, body mass index: 30.1±6.5 kg/m(2), duration of diabetes mellitus: 8.2±5.1 years, randomization BG: 194±97 mg/dL) were randomized to basal insulin (n=75) and OAD therapy (n=75). There were no differences in the mean fasting BG (131±27 mg/dL vs 123±23 mg/dL, p=0.06) between insulin and OAD groups, but patients treated with insulin had greater mean daily BG (163±39 mg/dL vs 138±27 mg/dL, p<0.001) compared to those treated with OADs. There were no differences in the rate of hypoglycemia (<70 mg/dL) between insulin (27%) and OAD (31%) groups, p=0.58. In addition, there were no differences in the number of hospital complications, emergency room visits, and mortality between treatment groups.
conclusionsThe results of this randomized study indicate that elderly patients with T2D in LTC facilities exhibited similar glycemic control, hypoglycemic events and complications when treated with either basal insulin or with oral antidiabetic drugs. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier: NCT01131052.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.