ArticleJournal of the Pediatric Infectious Diseases Society2015
Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants.
Article in Journal of the Pediatric Infectious Diseases Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- A randomized clinical trial to assess the effect of zinc and vitamin D supplementation in addition to hypertonic saline on treatment of acute bronchiolitis.BMC infectious diseases · 2022Trial
- Efficacy of vitamin D supplementation for children with acute bronchiolitis: A randomized controlled trial.World journal of clinical pediatrics · 2026Article
- Association of vitamin D with disease severity in infants with bronchiolitis.European journal of pediatrics · 2024Article
- Review
- Immunomodulatory Effects of Vitamin D in Respiratory Tract Infections and COVID-19 in Children.Nutrients · 2023Review
- Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study.BMC pediatrics · 2021Article
- Article
- Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes.Influenza and other respiratory viruses · 2020Article
- The Role of Micronutrients in Support of the Immune Response against Viral Infections.Nutrients · 2020Review
- Immune Modulatory Effects of Vitamin D on Viral Infections.Nutrients · 2020Review
- Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes.Nutrients · 2020Review
- Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection.The Journal of pediatrics · 2017Article
- Biomarkers for Predicting Illness Severity in Children With Acute Lower Respiratory Tract Infections.Journal of the Pediatric Infectious Diseases Society · 2015Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVitamin D deficiency at birth has been reported as a risk factor for respiratory syncytial virus (RSV) lower respiratory tract infection during the first year of life. Limited data are available on whether an infant's vitamin D status is associated with the severity of acute RSV bronchiolitis.
methodsInfants < 1 year of age and hospitalized with their first episode of RSV bronchiolitis were enrolled into the RSV Bronchiolitis in Early Life II cohort. We investigated the relationships between vitamin D status at enrollment and the following indicators of bronchiolitis severity: duration of hospitalization, lowest oxygen saturation measured during hospitalization, and bronchiolitis severity score.
resultsAmong the 145 enrolled infants, the median (quartile 1 [Q1], Q3) serum 25-OH-VitD level was 36.8 (29.8, 42.3) ng/mL, with 14 infants (9.7%) having deficient serum vitamin D levels (25-OH-VitD <20 ng/mL). Vitamin D-deficient infants were younger than infants with 25-OH-VitD ≥ 20 ng/mL (2.8 vs 4.5 months, respectively; P = .04) and were less likely to consume infant's formula (42.9% vs 87.0%, respectively; P < .01). The following indicators of acute bronchiolitis severity did not differ between infants who were vitamin D-deficient and nondeficient: duration of hospitalization (P = .53), lowest oxygen saturation (P = .45), and bronchiolitis severity score (P = .97), even after adjusting for age, and for infant's formula consumption.
conclusionsAmong this cohort of infants that were hospitalized for RSV bronchiolitis, vitamin D status at the time of bronchiolitis was not associated with indicators of acute bronchiolitis severity.
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