ArticleAnnals of Saudi medicine
The relationship between red cell distribution width and homozygous M694V mutation in familial Mediterranean fever patients.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Growth differentiation factor-15 as a potential biomarker in subclinical inflammation in familial mediterranean fever.Clinical rheumatology · 2026Article
- The Relationship Among the Level of Serum Amyloid A, High-Density Lipoprotein and Microalbuminuria in Patients With Familial Mediterranean Fever.Journal of clinical laboratory analysis · 2016Article
- Red cell distribution width is associated with albuminuria in adults with familial Mediterranean fever.The Kaohsiung journal of medical sciences · 2016Article
- Red Cell Distribution Width and Coronary Artery Calcification.Korean circulation journal · 2016Article
- Red Cell Distribution Width in Patients with Intermediate Coronary Artery Disease.Medical principles and practice : international journal of the Kuwait University, Health Science CentreArticle
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Authors and funding
8 authors.
Funding
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Abstract
BACKGROUND AND
objectiveFamilial Mediterranean fever (FMF) is characterized by recurrent and self-limiting attacks with peritonitis, pleuritis, arthritis, and erysipelas-like erythema. We aimed to investigate the red cell distribution width (RDW) level as an inflammatory marker in FMF patients compared with normal subjects. DESIGN AND SETTINGS: A retrospective study of FMF patients at the Department of Gastroenterology, Cumhuriyet University, between November 2011-February 2013.
methodsA total of 249 FMF patients and 131 age- and sex-matched control participants were included in the currrent study. RDW levels were also analyzed by standard methods. Each patient was given 2 mL of blood sample to obtain genomic DNA.
resultsStatistically significant differences were observed in RDW values between the FMF patients and the control group. Also, RDW levels were higher in the FMF patients with the homozygous M94V mutation compared with those with other mutations. The receiver-operating characteristic curve analysis suggested that the optimum RDW cutoff point for the FMF patients was 13.95, with a sensitivity, specificity, negative predictive value, and positive predictive value of 70%, 64%, 68%, and 66%, respectively (area under the curve: 0.711, 95% confidence interval 0.627-0.795, P < .0001).
conclusionWe suggest that RDW may show subclinical inflammation in FMF patients. RDW may be a promising marker in predicting the homozygous M694V mutation in FMF patients.
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