Evidence map›Paper›PMID 26336012›Full record

ReviewCurrent opinion in microbiology2015

High-throughput bacterial functional genomics in the sequencing era.

Andrew N Gray, Byoung-Mo Koo, Anthony L Shiver, Jason M Peters, Hendrik Osadnik, Carol A Gross

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Dynamic Transcriptional Landscape ofInternational journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. High-throughput functional variant screens via in vivo production of single-stranded DNA.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Chemical genetics in drug discovery.Current opinion in systems biology · 2017
    Review
  16. Article
  17. Article
  18. Review
  19. Molecular phenotyping of infection-associated small non-coding RNAs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew N GrayDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA.
Byoung-Mo KooDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA.
Anthony L ShiverGraduate Group in Biophysics, University of California, San Francisco, CA 94158, USA.
Jason M PetersDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA.
Hendrik OsadnikDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA.
Carol A GrossDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158, USA. Electronic address: cgrossucsf@gmail.com.

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
MUTATIONAL ANALYSIS OF E COLI CORE RNA POLYMERASER01GM057755 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, CAROL ANNE · 1998 to 2013
$6.2M
REGULATION OF THE HEAT-SHOCK RESPONSE IN E COLIR01GM036278 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI GROSS, CAROL ANNE · 1986 to 2016
$5.2M
Gene Function and Pathway Analysis Using Systems Level Approaches in ProkaryotesR01GM102790 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, CAROL ANNE · 2012 to 2015
$1.8M
Systematic Phenotypic Analysis of the Gram-positive EnvelopeF32GM108222 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETERS, JASON M. · 2013 to 2016
$161k
NIGMS NIH HHS F32 GM108222NIGMS NIH HHS R01 GM036278NIGMS NIH HHS R01GM036278NIGMS NIH HHS R01 GM057755NIGMS NIH HHS R01 GM102790NIGMS NIH HHS R01GM102790NIGMS NIH HHS T32 GM008284
6 · The paper itself

Abstract

High-throughput functional genomic technologies are accelerating progress in understanding the diversity of bacterial life and in developing a systems-level understanding of model bacterial organisms. Here we highlight progress in deep-sequencing-based functional genomics, show how whole genome sequencing is enabling phenotyping in organisms recalcitrant to genetic approaches, recount the rapid proliferation of functional genomic approaches to non-growth phenotypes, and discuss how advances are enabling genome-scale resource libraries for many different bacteria.

Indexed as

Genome, BacterialHigh-Throughput Nucleotide SequencingBacteriaDNA Barcoding, TaxonomicGenetic VariationGenomicsPhenotype

Identifiers

PMID26336012
PMCPMC4659725

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.