SynthesisJournal of the American Medical Informatics Association : JAMIA2015
Medication-indication knowledge bases: a systematic review and critical appraisal.
Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- DrugUtilisation: An R Package to Support Drug Utilisation Research Using the OMOP Common Data Model.Pharmacoepidemiology and drug safety · 2026Article
- Evaluating NLP Approaches to Extract Drug Indications.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026Article
- Medication Reconciliation during Transitions of Care Across Institutions: A Quantitative Analysis of Challenges and Opportunities.Applied clinical informatics · 2023Article
- Diabetes Mellitus and Its Therapy in Brunei Darussalam - A Critical Revisit.Patient preference and adherence · 2023Review
- Hierarchical Concept Relations Improve Detection of Off-Label Drug Use in Electronic Health Records Data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023Article
- The Intervention of Data Mining in the Allocation Efficiency of Multiple Intelligent Devices in Intelligent Pharmacy.Computational intelligence and neuroscience · 2022Article
- An updated, computable MEDication-Indication resource for biomedical research.Scientific reports · 2021Article
- InContext: curation of medical context for drug indications.Journal of biomedical semantics · 2021Article
- DICE: A Drug Indication Classification and Encyclopedia for AI-Based Indication Extraction.Frontiers in artificial intelligence · 2021Article
- Barriers and Facilitators to Implementation of Medication Decision Support Systems in Electronic Medical Records: Mixed Methods Approach Based on Structural Equation Modeling and Qualitative Analysis.JMIR medical informatics · 2020Article
- Medication stewardship using computerized clinical decision support: A case study on intravenous immunoglobulins.Pharmacology research & perspectives · 2019Article
- Developing a Data-driven Medication Indication Knowledge Base using a Large Scale Medical Claims Database.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019Article
- Monitoring prescribing patterns using regression and electronic health records.BMC medical informatics and decision making · 2017Article
- DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome.Scientific reports · 2016Article
- Disease-drug database for pharmacogenomic-based prescribing.Clinical pharmacology and therapeutics · 2016Article
- Pharmacy Informatics: Where Medication Use and Technology Meet.The Canadian journal of hospital pharmacyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveMedication-indication information is a key part of the information needed for providing decision support for and promoting appropriate use of medications. However, this information is not readily available to end users, and a lot of the resources only contain this information in unstructured form (free text). A number of public knowledge bases (KBs) containing structured medication-indication information have been developed over the years, but a direct comparison of these resources has not yet been conducted. MATERIAL AND
methodsWe conducted a systematic review of the literature to identify all medication-indication KBs and critically appraised these resources in terms of their scope as well as their support for complex indication information.
resultsWe identified 7 KBs containing medication-indication data. They notably differed from each other in terms of their scope, coverage for on- or off-label indications, source of information, and choice of terminologies for representing the knowledge. The majority of KBs had issues with granularity of the indications as well as with representing duration of therapy, primary choice of treatment, and comedications or comorbidities. DISCUSSION AND
conclusionThis is the first study directly comparing public KBs of medication indications. We identified several gaps in the existing resources, which can motivate future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.