ReviewHormones and behavior2015
Neuropeptidergic regulation of pair-bonding and stress buffering: Lessons from voles.
Review in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Paternal predatory risk alters parental behavior and offspring phenotypes in biparental Brandt's voles.Current zoology · 2025Article
- Article
- Expression of bond-related behaviors affects titi monkey responsiveness to oxytocin and vasopressin treatments.Annals of the New York Academy of Sciences · 2024Article
- What happens when the lights are left on? Transcriptomic and phenotypic habituation to light pollution.iScience · 2024Article
- Social defeat stress induces an anxiety-like outcome in male prairie voles (Oxford open neuroscience · 2024Article
- Partner-seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster).Genes, brain, and behavior · 2023Article
- Titi monkey father-daughter bond-related behaviors explain stress response variability.Psychoneuroendocrinology · 2023Article
- Is oxytocin receptor signaling really dispensable for social attachment?Comprehensive psychoneuroendocrinology · 2023Article
- Social buffering of the stress response: insights from fishes.Biology letters · 2022Review
- Behavioral, neurochemical, and neuroimmune changes associated with social buffering and stress contagion.Neurobiology of stress · 2022Article
- Behavioral trajectories of aging prairie voles (Microtus ochrogaster): Adapting behavior to social context wanes with advanced age.PloS one · 2022Article
- Social Buffering as a Tool for Improving Rodent Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Population variation alters aggression-associated oxytocin and vasopressin expressions in brains of Brandt's voles in field conditions.Frontiers in zoology · 2021Article
- Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward.International journal of molecular sciences · 2021Review
- Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia.Endocrinology · 2021Review
- Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles.Neurobiology of stress · 2020Article
- Behavioral and cardiovascular consequences of disrupted oxytocin communication in cohabitating pairs of male and female prairie voles.Social neuroscience · 2019Article
- Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.Neurotoxicity research · 2019Review
- Social Housing Conditions Modulate the Long-Lasting Increase in Cocaine Reward Induced by Intermittent Social Defeat.Frontiers in behavioral neuroscience · 2019Article
- Effects of aggressive temperament on endogenous oxytocin levels in adult titi monkeys.American journal of primatology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
This article is part of a Special Issue "SBN 2014". Interpersonal attachment is a critical component of the human experience. Pair-bonding ameliorates the severity of several mental and physical diseases. Thus, a better understanding of how the central nervous system responds to and encodes social-buffering during stress is a valuable research enterprise. The prairie vole (Microtus ochrogaster), as a laboratory animal model, provides the gold standard for the investigation of the neurobiology underlying attachment. Furthermore, emerging research in voles, additional laboratory rodents, transgenic mice, primates, and humans has provided novel insight into the neurochemical mechanisms underlying the therapeutic effects of social bonds reducing anxiety, depression, and drug abuse liability. In the present review, we highlight the work from this burgeoning field and focus on the role(s) of the neuropeptides oxytocin (OT), vasopressin (AVP), and corticotrophin releasing hormone (CRH) mediating stress buffering. Together, the data suggest that OT underlies social bonding to reduce stress-induced psychological illness while AVP and CRH facilitate arousal to enhance autonomic reactivity, increasing susceptibility to adverse mental and physical health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.