Evidence map›Paper›PMID 26335706›Full record

Observational studyBMC anesthesiology2015

Comparison of palonosetron, granisetron, and ramosetron for the prevention of postoperative nausea and vomiting after laparoscopic gynecologic surgery: a prospective randomized trial.

Won-Suk Lee, Kwang-Beom Lee, Soyi Lim, Young Gin Chang

Registry-linked trialOpen access · goldAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01752374 (Palonestron, Granisetron and Ramosetron for Prevention of Postoperative Nasea and Voming After Laparoscopic Abdominal Surgery), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01752374 completednot on this map

Palonestron, Granisetron and Ramosetron for Prevention of Postoperative Nasea and Voming After Laparoscopic Abdominal Surgery

TypeobservationalSponsorGachon University Gil Medical CenterRan2011Enrolled90ConditionsFemale Patients Undergoing Laparoscopic Abdominal Surgery
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. 5-HTInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Won-Suk LeeDepartment of Surgery, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. lws@gilhospital.com.
Kwang-Beom LeeDepartment of Gynecology, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. lws@gachon.ac.kr.
Soyi LimDepartment of Gynecology, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. doug.ws.lee@gmail.com.
Young Gin ChangDepartment of Anesthesiology Surgery, Gil Medical Center, Gachon University, School of Medicine, Incheon, South Korea. gachonlws@gmail.com.
Gachon University Gil Medical Center · KRGachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSelective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are reported to have potent antiemetic effects for postoperative nausea and vomiting (PONV). The purpose of this study was to prospectively evaluate the efficacy of palonosetron, granisetron, and ramosetron for the prevention of PONV in patients undergoing laparoscopic gynecologic surgery.

methodsIn this prospective, randomized observational study, 105 healthy female patients who were undergoing laparocopic hystectomy under general anaesthesia were enrolled (clinical trial number: NCT01752374, www.clinicaltrials.gov ). Patients were divided into three groups: the palonostron (0.075 mg i.v.; n = 35), the granisetron group (3 mg i.v.; n = 35), and the ramosetron group (0.3 mg i.v.; n = 35). The treatments were given before the end of surgery. The incidence of PONV, severity of nausea/vomiting, and the use of rescue antiemetic requirements during the first 48 h after surgery were evaluated.

resultsThe overall incidence of PONV was 33.3 % for this series. The number of complete responders at 48 h after the surgery was 21 (60.0 %) for palonosetron, 24 (68.6 %) for granisetron, and 26 (71.4 %) for ramosetron, representing no statistical difference (P = 0.086).

conclusionsThere were no significant differences in the overall incidence of postoperative nausea and vomiting and complete responders for palonosetron, granisetron and ramosetron group.

trial registrationCLINICAL TRIAL NUMBER: NCT01752374 , www.clinicaltrials.gov .

Indexed as

BenzimidazolesGranisetronGynecologic Surgical ProceduresIsoquinolinesLaparoscopyPostoperative Nausea and VomitingQuinuclidinesSerotonin 5-HT3 Receptor AntagonistsAdultAgedDouble-Blind MethodFemaleHumansMiddle AgedPalonosetronProspective StudiesBenzimidazolesGranisetronIsoquinolinesPalonosetronQuinuclidinesramosetronSerotonin 5-HT3 Receptor Antagonists

Identifiers

PMID26335706
PMCPMC4558835
OpenAlexW1848264649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.