Evidence map›Paper›PMID 26335665›Full record

ReviewCurrent opinion in oncology2015

Update on neurological paraneoplastic syndromes.

Romana Höftberger, Myrna R Rosenfeld, Josep Dalmau

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Efficacy of efgartigimod in the treatment of autoimmune encephalitis: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  5. 후뇌염의 영상 소견 스펙트럼: 임상 화보.Journal of the Korean Society of Radiology · 2026
    Review
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  9. Anti-NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
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  20. Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.Neurology(R) neuroimmunology & neuroinflammation · 2022
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Romana HöftbergeraInstitute of Neurology, Medical University of Vienna, Austria bDepartment of Neurology, Hospital Clínic /Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS) cInstitució Catalana de Recerca i Estudis Avançats (ICREA) and Hospital Clínic/ Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS).
Myrna R Rosenfeld
Josep Dalmau
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESMedical University of Vienna · AT

Funding

Paraneoplastic Disorders of the CNS: Autoantigen ProfilingR01NS077851 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2011 to 2015
$1.9M
NINDS NIH HHS R01 NS077851NINDS NIH HHS R01NS077851
6 · The paper itself

Abstract

purpose of reviewTo provide an update on paraneoplastic neurologic syndromes (PNS), the involved tumors, and types of immune responses. RECENT

findingsPNS are a diverse group of syndromes that may present as a relatively isolated syndrome such as predominant cerebellar degeneration or limbic encephalitis, or with more complex phenotypes such as diffuse encephalomyelitis that affects different levels of the neuraxis producing a variety of clinical manifestations. The detection of specific antineuronal antibodies can confirm or strongly support the paraneoplastic cause of the syndrome and direct the search for the associated cancer. Previously thought to be unresponsive to therapy, it has recently been shown that there are some antibody-associated PNS that are highly responsive to treatment, including tumor-directed therapies and immunotherapy. SUMMARY: The recognition of PNS is important for the early detection of an underlying malignancy and prompt initiation of therapies, which offers the best opportunity to stabilize or improve the neurological deficits and for those syndromes associated with cell surface antibodies usually results in substantial improvement or full recovery.

Indexed as

Antineoplastic AgentsHumansImmunotherapyMolecular Targeted TherapyParaneoplastic Syndromes, Nervous SystemAntineoplastic Agents

Identifiers

PMID26335665
PMCPMC4640358
OpenAlexW2213347440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.