ArticleNeuron2015
Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.eLife · 2024Article
- Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An alpha- to gamma-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement: A computational study.bioRxiv : the preprint server for biology · 2024Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.bioRxiv : the preprint server for biology · 2024Article
- Foramen lacerum impingement of trigeminal nerve root as a rodent model for trigeminal neuralgia.JCI insight · 2023Article
- Article
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
- Article
- Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome.Journal of neurodevelopmental disorders · 2019Article
- Crossed activation of thoracic trunk motoneurons by medullary reticulospinal neurons.Journal of neurophysiology · 2019Article
- Diverse physiological properties of hypoglossal motoneurons innervating intrinsic and extrinsic tongue muscles.Journal of neurophysiology · 2019Article
- Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.Development (Cambridge, England) · 2019Article
- Organization of motor pools depends on the combined function of N-cadherin and type II cadherins.Development (Cambridge, England) · 2019Article
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- Cell type and circuit modules in the spinal cord.Current opinion in neurobiology · 2019Review
- Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord.Frontiers in molecular neuroscience · 2019Article
- Sensory and descending motor circuitry during development and injury.Current opinion in neurobiology · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The coordination of multi-muscle movements originates in the circuitry that regulates the firing patterns of spinal motorneurons. Sensory neurons rely on the musculotopic organization of motorneurons to establish orderly connections, prompting us to examine whether the intraspinal circuitry that coordinates motor activity likewise uses cell position as an internal wiring reference. We generated a motorneuron-specific GCaMP6f mouse line and employed two-photon imaging to monitor the activity of lumbar motorneurons. We show that the central pattern generator neural network coordinately drives rhythmic columnar-specific motorneuron bursts at distinct phases of the locomotor cycle. Using multiple genetic strategies to perturb the subtype identity and orderly position of motorneurons, we found that neurons retained their rhythmic activity-but cell position was decoupled from the normal phasing pattern underlying flexion and extension. These findings suggest a hierarchical basis of motor circuit formation that relies on increasingly stringent matching of neuronal identity and position.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.