ArticleEuropean journal of applied physiology2015
Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exercise.
Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Factors Influencing the Hepcidin Response to Exercise: An Individual Participant Data Meta-analysis.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Trial
- Hepcidin response to three consecutive days of endurance training in hypoxia.European journal of applied physiology · 2021Trial
- Effect of low energy availability during three consecutive days of endurance training on iron metabolism in male long distance runners.Physiological reports · 2020Trial
- Trial
- The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers.Journal of the International Society of Sports Nutrition · 2018Trial
- Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels.Nutrients · 2017Trial
- Alterations in Hemoglobin and Serum 25-hydroxyvitamin D are Related Before and After Weight Loss Independent of African Admixture.International journal of sport nutrition and exercise metabolism · 2017Trial
- Effects of cranberry (Journal of the International Society of Sports Nutrition · 2017Trial
- Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levels.European journal of applied physiology · 2016Trial
- Article
- Hyperferritinemia Is Associated with Higher Adiposity, Metabolic Syndrome, and Hepatic Dysfunction, Mainly Affecting Men: A Study in Southern Brazil.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Patterns of energy availability and carbohydrate intake differentiate between adaptable and problematic low energy availability in female athletes.Frontiers in sports and active living · 2024Article
- Review
- Review
- Iron Status and Physical Performance in Athletes.Life (Basel, Switzerland) · 2023Review
- Article
- Heat acclimation does not attenuate hepcidin elevation after a single session of endurance exercise under hot condition.European journal of applied physiology · 2022Article
- Dietary Iron and the Elite Dancer.Nutrients · 2022Review
- Iron Metabolism following Twice a Day Endurance Exercise in Female Long-Distance Runners.Nutrients · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the effects of 24-h controlled carbohydrate intake on next day pre- and post-exercise inflammatory and hepcidin responses.
methodsIn a crossover design, 12 well-trained endurance athletes (Ht 181.08 ± 7.68 cm; Wt 74.8 ± 11.5 kg, VO 2peak 68.9 ± 7.2 ml kg(-1) min(-1)) completed two experimental (2-day) trials. On day 1, participants completed a glycogen depletion task, including a 16-km run (80 % vVO 2peak) and 5 × 1 min efforts (130 % vVO 2peak) separated by 2-min recovery. Subsequently, strict dietary control was enforced for 24 h, where low carbohydrate (LCHO 3 g kg(-1)) or high carbohydrate (HCHO 10 g kg(-1)) diets were provided. Twenty-four hours later, participants completed an 8 × 3 min interval running session at 85 % vVO 2peak followed by 3-h monitored recovery. Venous blood samples were collected pre-, immediately post- and 3-h post-exercise, which were analyzed for interleukin-6, serum iron, ferritin and hepcidin.
resultsInterleukin-6 was elevated (p < 0.001) immediately post-exercise compared to baseline in both conditions, but was lower in HCHO (p = 0.015). Hepcidin levels were also lower at baseline (p = 0.049) in HCHO, and a large effect (d = 0.72) indicated a trend for lower levels at 3-h post-exercise compared to LCHO. Serum iron was increased post-exercise for both trials (p = 0.001), whereas serum ferritin remained unchanged.
conclusionsTwenty-four hours of controlled low carbohydrate intake resulted in higher baseline hepcidin levels and post-exercise IL-6 responses than a high carbohydrate intake. Such hormone increases may be induced by gluconeogenic signaling of the liver, and may negatively impact an athlete's iron metabolism.
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