ArticleBritish journal of cancer2015
Postmenopausal mammographic breast density and subsequent breast cancer risk according to selected tissue markers.
Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A systematic review of the assessment model for palliative care needs in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Associations of alcohol consumption with expression of CD44, CD24, and ALDH1A1 stem cell markers in benign breast biopsy samples.Cancer causes & control : CCC · 2025Article
- Dense breast tissue in screened postmenopausal women: Prevalence and determinants.Saudi medical journal · 2024Article
- Associations of alcohol consumption with breast tissue composition.Breast cancer research : BCR · 2023Article
- A genome-wide association study of mammographic texture variation.Breast cancer research : BCR · 2022Article
- Correlation of Breast Density Grade on Mammogram With Diagnosed Breast Cancer: A Retrospective Cross-Sectional Study.Cureus · 2022Article
- Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study.NPJ breast cancer · 2021Article
- Quantitative Mammographic Density Measurements and Molecular Subtypes in Chinese Women With Breast Cancer.JNCI cancer spectrum · 2021Article
- Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk.Cancer causes & control : CCC · 2020Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
- Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer.Bioconjugate chemistry · 2019Article
- Mammographic density and breast cancer risk in breast screening assessment cases and women with a family history of breast cancer.European journal of cancer (Oxford, England : 1990) · 2018Article
- The correlation between mammographic densities and molecular pathology in breast cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Residential particulate matter and distance to roadways in relation to mammographic density: results from the Nurses' Health Studies.Breast cancer research : BCR · 2017Article
- Breast cancer risk prediction: an update to the Rosner-Colditz breast cancer incidence model.Breast cancer research and treatment · 2017Article
- The effect of volumetric breast density on the risk of screen-detected and interval breast cancers: a cohort study.Breast cancer research : BCR · 2017Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to determine if associations of pre-diagnostic percent breast density, absolute dense area, and non-dense area with subsequent breast cancer risk differ by the tumour's molecular marker status.
methodsWe included 1010 postmenopausal women with breast cancer and 2077 matched controls from the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II) cohorts. Breast density was estimated from digitised film mammograms using computer-assisted thresholding techniques. Information on breast cancer risk factors was obtained prospectively from biennial questionnaires. Polychotomous logistic regression was used to assess associations of breast density measures with tumour subtypes by the status of selected tissue markers. All tests of statistical significance were two sided.
resultsThe association of percent density with breast cancer risk appeared to be stronger in ER- as compared with ER+ tumours, but the difference did not reach statistical significance (density ⩾50% vs <10% odds ratio (OR)=3.06, 95% confidence interval (CI) 2.17-4.32 for ER+; OR=4.61, 95% CI 2.36-9.03 for ER-, Pheterogeneity=0.08). Stronger positive associations were found for absolute dense area and CK5/6- and EGFR- as compared with respective marker-positive tumours (Pheterogeneity=0.002 and 0.001, respectively). Stronger inverse associations of non-dense area with breast cancer risk were found for ER- as compared with ER+ tumours (Pheterogeneity=0.0001) and for AR+, CK5/6+, and EGFR+ as compared with respective marker-negative tumours (Pheterogeneity=0.03, 0.005, and 0.009, respectively). The associations of density measures with breast cancer did not differ by progesterone receptor and human epidermal growth factor receptor 2 status.
conclusionsBreast density influences the risk of breast cancer subtypes by potentially different mechanisms.
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