ReviewJournal of industrial microbiology & biotechnology2016
Metabolic profiling as a tool for prioritizing antimicrobial compounds.
Review in Journal of industrial microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.ACS chemical biology · 2024Article
- Discovering New Natural Products Using Metabolomics-Based Approaches.Advances in experimental medicine and biology · 2023Article
- Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.Scientific reports · 2022Article
- Bio-Guided Isolation of Antimalarial Metabolites from the Coculture of Two Red Sea Sponge-DerivedMarine drugs · 2021Article
- Evaluation of Sample Preparation Methods for Inter-Laboratory Metabolomics Investigation ofMetabolites · 2020Article
- Recent Advances in Strategies for Activation and Discovery/Characterization of Cryptic Biosynthetic Gene Clusters inMicroorganisms · 2020Review
- Article
- Study of in vitro interaction between Fusarium verticillioides and Streptomyces sp. using metabolomics.Folia microbiologica · 2020Article
- An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes.Metabolites · 2019Article
- Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae.The Journal of antibiotics · 2019Article
- Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.Journal of industrial microbiology & biotechnology · 2019Article
- Extreme EnvironmentInternational journal of microbiology · 2019Review
- Review
- Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.Proteomics · 2018Review
- Metabolomics and Biomarkers for Drug Discovery.Metabolites · 2018Article
- Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine.Journal of industrial microbiology & biotechnology · 2017Article
- Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow.Journal of natural products · 2017Article
- Pharmacological Potential of Phylogenetically Diverse Actinobacteria Isolated from Deep-Sea Coral Ecosystems of the Submarine Avilés Canyon in the Cantabrian Sea.Microbial ecology · 2017Article
- The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production.Synthetic and systems biotechnology · 2016Review
- Natural product discovery: past, present, and future.Journal of industrial microbiology & biotechnology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is an analytical technique that allows scientists to globally profile low molecular weight metabolites between samples in a medium- or high-throughput environment. Different biological samples are statistically analyzed and correlated to a bioactivity of interest, highlighting differentially produced compounds as potential biomarkers. Here, we review NMR- and MS-based metabolomics as technologies to facilitate the identification of novel antimicrobial natural products from microbial sources. Approaches to elicit the production of poorly expressed (cryptic) molecules are thereby a key to allow statistical analysis of samples to identify bioactive markers, while connection of compounds to their biosynthetic gene cluster is a determining step in elucidating the biosynthetic pathway and allows downstream process optimization and upscaling. The review focuses on approaches built around NMR-based metabolomics, which enables efficient dereplication and guided fractionation of (antimicrobial) compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.