ArticleeLife2015
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- CaMK modulates sensory neural activity to control longevity and proteostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in aeLife · 2023Article
- Dauer fate in aPeerJ · 2023Article
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- Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type.PLoS biology · 2022Article
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- CaeLife · 2021Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Chronic vs acute manipulations reveal degeneracy in a thermosensory neuron network.microPublication biology · 2021Article
- Starvation Responses Throughout theGenetics · 2020Review
- Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity.eLife · 2020Article
- A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans.Scientific reports · 2020Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron.Nature communications · 2018Article
- Loss of CaMKI Function Disrupts Salt Aversive Learning inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state. CMK-1 acts cell-autonomously in the ASI, and non cell-autonomously in the AWC, sensory neurons to regulate expression of the growth promoting daf-7 TGF-β and daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state regulates dynamic subcellular localization of CMK-1, and CMK-1-dependent expression of anti-dauer ILP genes, in AWC. A food-regulated balance between anti-dauer ILP signals from AWC and pro-dauer signals regulates neuroendocrine signaling and dauer entry; disruption of this balance in cmk-1 mutants drives inappropriate dauer formation under well-fed conditions. These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.