ReviewCurrent opinion in clinical nutrition and metabolic care2015
Sirtuin-dependent clock control: new advances in metabolism, aging and cancer.
Review in Current opinion in clinical nutrition and metabolic care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Aberrant DNA methylation within circadian entrainment and clock genes two years after pediatric critical illness is associated with impaired physical and neurocognitive development.Clinical epigenetics · 2025Trial
- Emerging roles of SIRT6 and its modulators in kidney diseases.Cell death discovery · 2026Review
- Pharmacological Foundation and Novel Insights of Resveratrol in Cardiovascular System: A Review.Current cardiology reviews · 2026Review
- Acrolein-triggered atherosclerosisJournal of biomedical research · 2024Article
- Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.Sub-cellular biochemistry · 2024Review
- An integrated bioinformatics analysis to identify the shared biomarkers in patients with obstructive sleep apnea syndrome and nonalcoholic fatty liver disease.Frontiers in genetics · 2024Article
- Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations.Journal of chemical information and modeling · 2023Article
- Article
- Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications.Brain sciences · 2023Article
- Review
- Redox Biology of Melatonin: Discriminating Between Circadian and Noncircadian Functions.Antioxidants & redox signaling · 2022Review
- Review
- Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts.The FEBS journal · 2022Review
- A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19.Frontiers in nutrition · 2022Review
- Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1.Cellular and molecular life sciences : CMLS · 2021Review
- Emerging roles of SIRT6 in human diseases and its modulators.Medicinal research reviews · 2021Review
- NADSignal transduction and targeted therapy · 2021Review
- Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer.Nature reviews. Endocrinology · 2020Review
- Metabolic implications of circadian disruption.Pflugers Archiv : European journal of physiology · 2020Review
- Mitochondrial Dysfunction in Age-Related Metabolic Disorders.Proteomics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe circadian clock is an intricate biological timekeeper that is subject to fine-tuning mechanisms in order to maintain synchrony with the surrounding environment. One such mechanism is performed by the mammalian sirtuins that provide plasticity to the circadian clock by sensing cellular metabolic state. The sirtuins modulate the circadian epigenome and subsequent transcriptional control, and alterations to this organized system manifest in metabolic consequences, aging phenotypes and possibly cancer. RECENT
findingsNew information regarding sirtuin-dependent control of the circadian clock has emerged. In addition to sirtuin (SIRT)1 and SIRT3, SIRT6 has been demonstrated as a critical regulator of circadian transcription that also serves as an interface with metabolic homeostasis. Also, new metabolic functions of SIRT1 have been described in the brain, which are critical to relay nutritional inputs to the central clock. SUMMARY: This review focuses on the link between the circadian clock and the sirtuins, with an emphasis on new findings. In addition, speculation on the possible connections at the physiological level will be made that could further link the clock to aging and cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.