Evidence map›Paper›PMID 26335307›Full record

ReviewThe AAPS journal2015

Therapeutic Applications of Curcumin Nanoformulations.

Murali M Yallapu, Prashanth K Bhusetty Nagesh, Meena Jaggi, Subhash C Chauhan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The AAPS journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 1 synthesis or guideline pooled it.

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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Murali M YallapuDepartment of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA. myallapu@uthsc.edu.
Prashanth K Bhusetty NageshDepartment of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA.
Meena JaggiDepartment of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA.
Subhash C ChauhanDepartment of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA. myallapu@uthsc.edu.

Funding

Etiology of cervical cancer health disparity in American Indian womenU01CA162106 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHAUHAN, SUBHASH C., JAGGI, MEENA · 2012 to 2016
$1.5M
Aspects of MUC13 Mucin in CancerR01CA142736 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHAUHAN, SUBHASH C. · 2010 to 2013
$1.2M
PSMA Targeted Docetaxel Loaded Magnetic Nanoparticles for Prostate Cancer TherapyK22CA174841 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI YALLAPU, MURALI MOHAN · 2015 to 2017
$485k
NCI NIH HHS K22 CA174841NCI NIH HHS R01 CA142736NCI NIH HHS R01CA142736NCI NIH HHS U01 CA142736NCI NIH HHS U01 CA162106
6 · The paper itself

Abstract

Curcumin (diferuloylmethane) is a bioactive and major phenolic component of turmeric derived from the rhizomes of curcuma longa linn. For centuries, curcumin has exhibited excellent therapeutic benefits in various diseases. Owing to its anti-oxidant and anti-inflammatory properties, curcumin plays a significant beneficial and pleiotropic regulatory role in various pathological conditions including cancer, cardiovascular disease, Alzheimer's disease, inflammatory disorders, neurological disorders, and so on. Despite such phenomenal advances in medicinal applications, the clinical implication of native curcumin is hindered due to low solubility, physico-chemical instability, poor bioavailability, rapid metabolism, and poor pharmacokinetics. However, these issues can be overcome by utilizing an efficient delivery system. Active scientific research was initiated in 2005 to improve curcumin's pharmacokinetics, systemic bioavailability, and biological activity by encapsulating or by loading curcumin into nanoform(s) (nanoformulations). A significant number of nanoformulations exist that can be translated toward medicinal use upon successful completion of pre-clinical and human clinical trials. Considering this perspective, current review provides an overview of an efficient curcumin nanoformulation for a targeted therapeutic option for various human diseases. In this review article, we discuss the clinical evidence, current status, and future opportunities of curcumin nanoformulation(s) in the field of medicine. In addition, this review presents a concise summary of the actions required to develop curcumin nanoformulations as pharmaceutical or nutraceutical candidates.

Indexed as

AnimalsAnti-Inflammatory AgentsChemistry, PharmaceuticalCurcuminDrug Delivery SystemsHumansNanotechnologyNeoplasmsNervous System DiseasesAnti-Inflammatory AgentsCurcumincancercurcumindrug deliverynanoparticlesnanotechnology

Identifiers

PMID26335307
PMCPMC4627456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.